Combined imaging biomarkers for therapy evaluation in glioblastoma multiforme: correlating sodium MRI and F-18 FLT PET on a voxel-wise basis.
Combined imaging biomarkers for therapy evaluation in glioblastoma multiforme: correlating sodium MRI and F-18 FLT PET on a voxel-wise basis.
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DOI：
10.1016/j.mri.2012.05.011
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发表时间：
2012-11
影响因子：
2.5
通讯作者：
Mountz, James M.
中科院分区：
文献类型：
--
作者：
Laymon, Charles M.;Oborski, Matthew J.;Lee, Vincent K.;Davis, Denise K.;Wiener, Erik C.;Lieberman, Frank S.;Boada, Fernando E.;Mountz, James M.
我们评估了新的磁共振成像（MRI）和正电子发射断层扫描（PET）定量成像生物标志物和相关的多模态，连续时间点分析方法，最终目的是提供临床可行的，预测措施，早期评估癌症治疗的反应。这项工作的一个重点是方法的发展和两种模式的信息内容之间的关系的调查。对入组多形性胶质母细胞瘤（GBM）治疗性临床试验的受试者进行成像研究。使用可适用于临床使用的方法采集、分析和显示数据。受试者在基线（开始治疗前）、开始治疗后早期时间点和治疗后晚期随访时间点接受动态[18 F]氟胸苷（F-18 FLT）PET、钠（23 Na）MRI和3-T结构MRI扫描。将钠MRI和F-18 FLT PET图像与结构MRI配准。基于体素计算F-18 FLT PET示踪剂分布体积和钠MRI浓度，以解决肿瘤生理学的异质性。跟踪这些量随扫描时间的变化和差异。虽然这两种模式独立地显示了作为扫描时间点的函数的组织状态的变化，但结果表明，这两种模式可以提供关于肿瘤进展和反应的互补信息。此外，发现肿瘤状态变化在肿瘤的不同区域中不同。这些方法用于GBM治疗反应评估，特别是用于区分真实进展与假进展的程度需要额外的患者数据和这些成像生物标志物变化与临床结果的相关性。
We evaluate novel magnetic resonance imaging (MRI) and positron emission tomography (PET) quantitative imaging biomarkers and associated multimodality, serial-time-point analysis methodologies, with the ultimate aim of providing clinically feasible, predictive measures for early assessment of response to cancer therapy. A focus of this work is method development and an investigation of the relationship between the information content of the two modalities. Imaging studies were conducted on subjects who were enrolled in glioblastoma multiforme (GBM) therapeutic clinical trials. Data were acquired, analyzed and displayed using methods that could be adapted for clinical use. Subjects underwent dynamic [18F]fluorothymidine (F-18 FLT) PET, sodium (23Na) MRI and 3-T structural MRI scans at baseline (before initiation of therapy), at an early time point after beginning therapy and at a late follow-up time point after therapy. Sodium MRI and F-18 FLT PET images were registered to the structural MRI. F-18 FLT PET tracer distribution volumes and sodium MRI concentrations were calculated on a voxel-wise basis to address the heterogeneity of tumor physiology. Changes in, and differences between, these quantities as a function of scan timing were tracked. While both modalities independently show a change in tissue status as a function of scan time point, results illustrate that the two modalities may provide complementary information regarding tumor progression and response. Additionally, tumor status changes were found to vary in different regions of tumor. The degree to which these methods are useful for GBM therapy response assessment and particularly for differentiating true progression from pseudoprogression requires additional patient data and correlation of these imaging biomarker changes with clinical outcome.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.1007/s00259-004-1742-3
发表时间：
2005-06-01
影响因子：
9.1
作者：
Choi, SJ;Kim, JS;Moon, DH
通讯作者：
Moon, DH
影响因子：
45.3
作者：
Chen, Wei;Delaloye, Sibylle;Cloughesy, Timothy
通讯作者：
Cloughesy, Timothy
影响因子：
6.3
作者：
LOGAN, J;FOWLER, JS;CHRISTMAN, DR
通讯作者：
CHRISTMAN, DR
影响因子：
45.3
作者：
MACDONALD, DR;CASCINO, TL;CAIRNCROSS, JG
通讯作者：
CAIRNCROSS, JG