Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation.

Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation.
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DOI:
10.3389/fpls.2023.1120841
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发表时间:
2023
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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细胞板是由分裂平面中心的小泡融合形成的暂态结构;此外,这些是新细胞壁的前体,对胞质分裂是必不可少的。细胞板的形成需要细胞骨架重排、囊泡堆积和融合以及膜成熟的高度协调过程。研究表明,系留因子与RAS超家族的小GTP结合蛋白(RAB GTP酶)和可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体(SNARs)相互作用,它们在细胞质分裂过程中对细胞板的形成是必不可少的,并且对维持植物的正常生长发育是基本的。在拟南芥中,Rab GTP酶、系链和圈套的成员定位于细胞板,编码这些蛋白的基因突变会导致典型的细胞质分裂缺陷表型,如形成异常的细胞板、多核细胞和不完整的细胞壁。这篇综述重点介绍了最近关于Rab GTP酶、绳索和圈套介导的细胞板形成过程中的囊泡运输的研究结果。
Cell plates are transient structures formed by the fusion of vesicles at the center of the dividing plane; furthermore, these are precursors to new cell walls and are essential for cytokinesis. Cell plate formation requires a highly coordinated process of cytoskeletal rearrangement, vesicle accumulation and fusion, and membrane maturation. Tethering factors have been shown to interact with the Ras superfamily of small GTP binding proteins (Rab GTPases) and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), which are essential for cell plate formation during cytokinesis and are fundamental for maintaining normal plant growth and development. In Arabidopsis thaliana, members of the Rab GTPases, tethers, and SNAREs are localized in cell plates, and mutations in the genes encoding these proteins result in typical cytokinesis-defective phenotypes, such as the formation of abnormal cell plates, multinucleated cells, and incomplete cell walls. This review highlights recent findings on vesicle trafficking during cell plate formation mediated by Rab GTPases, tethers, and SNAREs.
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