Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study).
Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study).
复制标题
DOI：
10.1016/j.jacc.2009.06.017
复制
发表时间：
2009-09-22
影响因子：
24
通讯作者：
Criqui, Michael H.
中科院分区：
文献类型：
--
作者：
Ix, Joachim H.;Katz, Ronit;De Boer, Ian H.;Kestenbaum, Brian R.;Allison, Matthew A.;Siscovick, David S.;Newman, Anne B.;Sarnak, Mark J.;Shlipak, Michael G.;Criqui, Michael H.
慢性肾脏疾病(CKD)是心血管疾病(CVD)事件的重要危险因素。高踝臂指数(ABI)--下肢动脉僵硬的标志--与心血管疾病事件和死亡率有关。CKD和高ABI之间的联系尚不清楚。心血管健康研究招募了65岁的社区居民，并测量了肾功能和ABI。肾小球滤过率(GFR)是使用包含胱抑素C或肌酐的方程来估计的，而CKD是由估计的GFR和60ml/min/1.73m2来定义的。ABI分为低(0.90)、低正常(0.90-1.09)、正常(1.10-1.40)和高(1.40或不可压缩)。用多项Logistic回归分析慢性肾脏病与ABI分类的相关性。在4513名参与者中，23%的人患有慢性肾脏病，13%的人ABI低，3%的人ABI高。在调整了年龄、性别、种族、高血压、糖尿病、吸烟、体重指数、低密度脂蛋白、高密度脂蛋白、高密度脂蛋白和C反应蛋白的模型中，基于胱抑素C的慢性肾脏病与低ABI(相对危险度为2.0；95%可信区间为1.6-2.5；P值为0.001)和高ABI(相对危险度为1.6；95%CI1.0-2.3；P=0.0 3)有关。用肌酐定义慢性肾脏病的结果与此相似。慢性肾脏病与社区老年人ABI的高、低两个极端有关。未来的研究应该评估动脉僵硬是否是导致CKD患者心血管疾病的重要机制。
Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD) events. A high ankle brachial index (ABI) - a marker of lower extremity arterial stiffness – is associated with CVD events and mortality. The association between CKD and high ABI is unknown. The Cardiovascular Health Study enrolled community-living persons > 65 years, and measured kidney function and ABI. Glomerular filtration rate (GFR) was estimated using equations that incorporated either cystatin C or creatinine, and CKD was defined by estimated GFR < 60 ml/min/1.73m2. The ABI was categorized as low (< 0.90), low-normal (0.90 – 1.09), normal (1.10 – 1.40), and high (> 1.40 or incompressible). Multinomial logistic regression was used to evaluate the associations of CKD with the ABI categories. Among 4,513 participants, 23% had CKD, 13% had low ABI, and 3% had high ABI. In models adjusted for age, sex, race, hypertension, diabetes, smoking, BMI, LDL cholesterol, HDL cholesterol, and CRP, cystatin C based CKD was associated with both low ABI (relative risk [RR] 2.0; 95% confidence interval [CI] 1.6 – 2.5; P value < 0.001) and high ABI (RR 1.6; 95% CI 1.0 – 2.3; P = 0.03). Results were similar when CKD was defined by creatinine. CKD is associated with both the high and low extremes of ABI in community-living older persons. Future studies should evaluate whether arterial stiffness is an important mechanism leading to CVD in persons with CKD.
登录
查看更多内容
影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
影响因子：
13.6
作者：
Kramer, H;Toto, R;Victor, R
通讯作者：
Victor, R
影响因子：
5.3
作者：
MCKENNA, M;WOLFSON, S;KULLER, L
通讯作者：
KULLER, L
影响因子：
5.7
作者：
MCDERMOTT, MM;FEINGLASS, J;PEARCE, WH
通讯作者：
PEARCE, WH