A preference for mathematical processing outweighs the selectivity for Arabic numbers in the inferior temporal gyrus.

A preference for mathematical processing outweighs the selectivity for Arabic numbers in the inferior temporal gyrus.
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DOI:
10.1016/j.neuroimage.2018.03.064
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发表时间:
2018-07-15
期刊:
影响因子:
5.7
通讯作者:
Grill-Spector K
Grill-Spector K
中科院分区:
医学1区
文献类型:
--
作者:
Grotheer M;Jeska B;Grill-Spector K

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后颞下回(ITG)中的一个区域,被称为数字形式区(NFA,这里ITG数字),与阿拉伯数字的视觉处理有关。然而,目前还不清楚这个区域是否涉及阿拉伯数字本身的视觉编码或更广泛的数学处理。使用功能性磁共振成像在实验中,系统地改变任务和刺激,我们发现,数学处理,而不是偏好阿拉伯数字,一贯驱动平均和分布式响应后ITG。虽然我们复制的ITG-数字的数字比其他视觉刺激在1-回任务的反应更高的研究结果,这种偏好的数字被废除时,参与者从事数学处理。相比之下,ITG区域(ITG-数学)在添加任务与其他任务期间显示出更高的反应,在包括数字,数字/字母变体,手和骰子在内的广泛刺激中保持了这种对数学处理的偏好。通过对解剖学定义的后ITG扩展区的分布响应的分析,进一步揭示了数学任务而不是阿拉伯数字形式可以从这些分布响应中成功且一致地解码。总之,我们的研究结果表明,在后ITG的神经元区域的功能超出了特定的阿拉伯数字的视觉处理。我们假设,他们归因于数字内容的视觉输入,不管刺激的格式。
A region in the posterior inferior temporal gyrus (ITG), referred to as the number form area (NFA, here ITG-numbers) has been implicated in the visual processing of Arabic numbers. However, it is unknown if this region is involved in the visual encoding of Arabic numbers per se or in mathematical processing more broadly. Using fMRI during experiments that systematically vary tasks and stimuli, we find that mathematical processing, not preference to Arabic numbers, consistently drives both mean and distributed responses in the posterior ITG. While we replicated findings of higher responses in ITG-numbers to numbers than other visual stimuli during a 1-back task, this preference to numbers was abolished when participants engaged in mathematical processing. In contrast, an ITG region (ITG-math) that showed higher responses during an adding task vs. other tasks maintained this preference for mathematical processing across a wide range of stimuli including numbers, number/letter morphs, hands, and dice. Analysis of distributed responses across an anatomically-defined posterior ITG expanse further revealed that mathematical task but not Arabic number form can be successfully and consistently decoded from these distributed responses. Together, our findings suggest that the function of neuronal regions in the posterior ITG goes beyond the specific visual processing of Arabic numbers. We hypothesize that they ascribe numerical content to the visual input, irrespective of the format of the stimulus.
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