Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice.
Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice.
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DOI：
10.1293/tox.22.179
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发表时间：
2009-09
影响因子：
1.2
通讯作者：
Imaida K
中科院分区：
文献类型：
--
作者：
Yokohira M;Hashimoto N;Yamakawa K;Suzuki S;Saoo K;Kuno T;Imaida K
本研究的目的是调查炎症的影响，诱导的intrichloroheal滴注（i.t.）在用NNK启动的雌性A/J小鼠中，在肺中饮用石英作为环境因素或在结肠中饮用葡聚糖硫酸钠（DSS）作为环境因素对肺肿瘤的影响。为了比较，还评估了结肠癌前病变、异常隐窝病灶（ACF）。将6周龄的A/J小鼠分成5组，第1、2和3组在第0周用NNK（2 mg /0.1ml盐水/小鼠，腹膜内注射）预处理。从第1周开始，向第2组和第4组的小鼠施用2%DSS的饮用水溶液一周。在第2周，将第3组和第5组的小鼠暴露于悬于25 μl盐水中的石英（0.1 mg/大鼠）的腹膜内滴注。实验在16周后结束。肺肿瘤和结肠ACF的结果显示，在任一部位均缺乏炎症的修饰作用。在16周结束时，血液学和组织病理学上，肺中0.1 mg石英和结肠中2%DSS诱导的炎症缺乏或仅为轻度。这些结果表明，对炎症的敏感性可能存在差异，这些差异决定了肿瘤促进潜力。
The purpose of the present study was to investigate the effects of inflammation, induced by intratracheal instillation (i.t.) of quartz as an environmental factor in the lung or drinking of dextran sulfate sodium (DSS) as an environmental factor in the colon on lung tumors in female A/J mice initiated with NNK. For comparison, colonic preneoplastic lesions, aberrant crypt foci (ACF), were also assessed. A/J mice at 6 weeks of age were divided into 5 groups, and Groups 1, 2 and 3 were pretreated with NNK (2 mg / 0.1 ml saline / mouse, intraperitoneal injection) at week 0. For a week, 2% DSS in drinking water was administered to the mice in Groups 2 and 4 beginning in week 1. In week 2, the mice of Groups 3 and 5 were exposed to intratracheal instillation of quartz (0.1 mg/rat) suspended in 25 μl saline. The experiment was terminated after 16 weeks. The results for the lung tumors and colonic ACFs showed a lack of modifying effects of the inflammation in either site. Hematologically and histopathologically, the inflammation induced by 0.1 mg quartz in the lung and 2% DSS in the colon was lacking or only mild at the end of 16 weeks. These results suggest that there may be differences in sensitivity to inflammation that determine tumor promoting potential.
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影响因子：
3.9
作者：
Draper, AJ;Madan, A;Parkinson, A
通讯作者：
Parkinson, A
影响因子：
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作者：
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