The role of the gut and microbes in the pathogenesis of spondyloarthritis.
The role of the gut and microbes in the pathogenesis of spondyloarthritis.
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DOI：
10.1016/j.berh.2014.10.018
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Rosenbaum JT
中科院分区：
文献类型：
--
作者：
Asquith M;Elewaut D;Lin P;Rosenbaum JT
肠道微生物群不仅与炎症性肠病（IBD）的发病机制密切相关，而且越来越多地与肠外组织部位的炎症发展有关。IBD和脊柱关节炎（SpA）之间存在显著的临床、遗传、免疫学和微生物学重叠，这表明这些疾病之间的病理生理机制是共享的，并且可能以肠道微生物群为中心。最近，非培养技术使健康和疾病中的微生物群得到了越来越详细的描述。此外，功能研究已经确定了无数的宿主效应和调节途径，形状或由这种微生物群落形成。我们认为SpA的发病机制和肠道微生物之间的复杂关系，如何操纵肠道微生物群本身可能是一个有前途的SpA治疗的未来目标的讨论。
The intestinal microbiota is firmly implicated not only in the pathogenesis of inflammatory bowel disease (IBD) but increasingly also in the development of inflammation at extraintestinal tissue sites. Significant clinical, genetic, immunological, and microbio-logical overlap exists between IBD and spondyloarthritis (SpA), which indicates that pathophysiological mechanisms are shared between these diseases and may center on the intestinal micro-biota. Recently, culture-independent techniques have enabled the microbiota in health and disease to be described in increasing detail. Moreover, functional studies have identified myriad host effector and regulatory pathways that shape or are shaped by this microbial community. We consider the complex relationship between SpA pathogenesis and gut microbes, with a discussion of how manipulation of the gut microbiota itself may be a promising future target for SpA therapy.
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影响因子：
27.4
作者：
Ciccia F;Accardo-Palumbo A;Rizzo A;Guggino G;Raimondo S;Giardina A;Cannizzaro A;Colbert RA;Alessandro R;Triolo G
通讯作者：
Triolo G
用于评估互补药物和替代药物的基于Internet的随机对照试验：脊椎关节炎中的益生菌。
影响因子：
2.3
作者：
Brophy S;Burrows CL;Brooks C;Gravenor MB;Siebert S;Allen SJ
通讯作者：
Allen SJ
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5.4
作者：
AUSTRUP, F;REBSTOCK, S;HAMANN, A
通讯作者：
HAMANN, A