Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.
Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.
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DOI：
10.1007/82_2017_56
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发表时间：
2018
影响因子：
--
通讯作者：
Shoulders MD
中科院分区：
文献类型：
--
作者：
Wong MY;DiChiara AS;Suen PH;Chen K;Doan ND;Shoulders MD
Cells address challenges to protein folding in the secretory pathway by engaging endoplasmic reticulum (ER)-localized protective mechanisms that are collectively termed the unfolded protein response (UPR). By the action of the transmembrane signal transducers IRE1, PERK, and ATF6, the UPR induces networks of genes whose products alleviate the burden of protein misfolding. The UPR also plays instructive roles in cell differentiation and development, aids in the response to pathogens, and coordinates the output of professional secretory cells. These functions add to and move beyond the UPR’s classical role in addressing proteotoxic stress. Thus, the UPR is not just a reaction to protein misfolding, but also a fundamental driving force in physiology and pathology. Recent efforts have yielded a suite of chemical genetic methods and small molecule modulators that now provide researchers with both stress-dependent and -independent control of UPR activity. Such tools provide new opportunities to perturb the UPR and thereby study mechanisms for maintaining proteostasis in the secretory pathway. Numerous observations now hint at the therapeutic potential of UPR modulation for diseases related to the misfolding and/or aggregation of ER client proteins. Growing evidence also indicates the promise of targeting ER proteostasis nodes downstream of the UPR. Here, we review selected advances in these areas, providing a resource to inform ongoing studies of secretory proteostasis and function as they relate to the UPR.
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影响因子：
30.3
作者：
Cho JA;Lee AH;Platzer B;Cross BCS;Gardner BM;De Luca H;Luong P;Harding HP;Glimcher LH;Walter P;Fiebiger E;Ron D;Kagan JC;Lencer WI
通讯作者：
Lencer WI
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Carrara M;Prischi F;Nowak PR;Kopp MC;Ali MM
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Ali MM
DOI：
10.1126/science.aaa4484
发表时间：
2015-04-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Das I;Krzyzosiak A;Schneider K;Wrabetz L;D'Antonio M;Barry N;Sigurdardottir A;Bertolotti A
通讯作者：
Bertolotti A
影响因子：
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影响因子：
1.5
作者：
Adachi, Yusuke;Yamamoto, Keisuke;Mori, Kazutoshi
通讯作者：
Mori, Kazutoshi