Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.
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DOI：
10.1016/j.ccell.2017.05.009
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发表时间：
2017-07-10
期刊：
影响因子：
50.3
通讯作者：
TIGER-LC Consortium
中科院分区：
文献类型：
--
作者：
Chaisaingmongkol J;Budhu A;Dang H;Rabibhadana S;Pupacdi B;Kwon SM;Forgues M;Pomyen Y;Bhudhisawasdi V;Lertprasertsuke N;Chotirosniramit A;Pairojkul C;Auewarakul CU;Sricharunrat T;Phornphutkul K;Sangrajrang S;Cam M;He P;Hewitt SM;Ylaya K;Wu X;Andersen JB;Thorgeirsson SS;Waterfall JJ;Zhu YJ;Walling J;Stevenson HS;Edelman D;Meltzer PS;Loffredo CA;Hama N;Shibata T;Wiltrout RH;Harris CC;Mahidol C;Ruchirawat M;Wang XW;TIGER-LC Consortium
肝内胆管细胞癌（ICC）和肝细胞癌（HCC）是临床上不同的原发性肝癌，具有病因和生物学异质性。我们通过基因组学、转录组学和代谢组学的系统整合，在199名泰国ICC和HCC患者中确定了与相似预后相关的常见分子亚型。虽然ICC和HCC共享反复突变的基因，包括TP53，ARID1A和ARID2，但有丝分裂检查点异常将C1亚型与关键驱动因子PLK1和ECT2区分开来，而C2亚型与肥胖，T细胞浸润和胆汁酸代谢有关。这些分子亚型在582名亚洲人中发现，但在265名白人患者中较少。因此，亚洲ICC和HCC虽然在临床上作为单独的实体进行治疗，但具有共同的分子亚型，具有相似的可操作驱动因素，以改善精确治疗。
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients through systems integration of genomics, transcriptomics, and metabolomics. While ICC and HCC share recurrently mutated genes, including TP53, ARID1A, and ARID2, mitotic checkpoint anomalies distinguish the C1 subtype with key drivers PLK1 and ECT2, whereas the C2 subtype is linked to obesity, T-cell infiltration and bile acid metabolism. These molecular subtypes are found in 582 Asian, but less so in 265 Caucasian patients. Thus, Asian ICC and HCC, while clinically treated as separate entities, share common molecular subtypes with similar actionable drivers to improve precision therapy.
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影响因子：
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