Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats.
Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats.
复制标题
DOI：
10.1186/s12871-015-0013-0
复制
发表时间：
2015
影响因子：
2.2
通讯作者：
Koch T
中科院分区：
文献类型：
--
作者：
Richter T;Bergmann R;Musch G;Pietzsch J;Koch T
吸入性肺损伤可减少气体交换并增加死亡率。酸吸入后的急性肺损伤的特征是在早期炎症阶段受损肺区域的肺血流量（PBF）升高。了解酸吸入后PBF模式对于靶向静脉内治疗很重要。我们在后期（损伤后2小时）检查了实验模型中的PBF。麻醉的Wistar-Unilever大鼠（n = 5）接受单侧支气管内滴注盐酸。PBF分布在损伤和未损伤侧之间进行比较，并与未处理的对照动物（n = 6）进行比较。使用计算机断层扫描（CT）测量损伤后肺密度的变化。局部PBF分布定量测定体内酸滴注后2小时，通过测量浓度的[68 Ga]-放射性标记的微球，使用正电子发射断层扫描。CT扫描显示酸吸入区域的肺密度增加。肺损伤伴有气体交换受损。酸吸入使动脉血氧分压在20分钟时从157 mmHg [139;165]降至74 mmHg [67;86]，并在110分钟时趋于恢复至109 mmHg [69;114]（P < 0.001）。抽吸组损伤肺与未损伤肺中间区域的PBF比值（0.86 [0.7;0.9]，中位数[25%;75%]）显著低于对照组左肺与右肺的PBF比值（1.02 [1.0;1.05]; P = 0.016）。吸入诱导的肺损伤后2小时的PBF模式显示PBF远离损伤区域的重新分布，这可能是随着时间的推移从低氧血症中部分恢复的原因。酸诱导的肺损伤后2小时静脉内给予的治疗可能不会优先到达受伤的肺区域，与炎症发生的第一个小时相反。请参阅相关文章：http://dx.doi.org/10.1186/s12871-015-0014-z。
Aspiration-induced lung injury can decrease gas exchange and increase mortality. Acute lung injury following acid aspiration is characterized by elevated pulmonary blood flow (PBF) in damaged lung areas in the early inflammation stage. Knowledge of PBF patterns after acid aspiration is important for targeting intravenous treatments. We examined PBF in an experimental model at a later stage (2 hours after injury). Anesthetized Wistar-Unilever rats (n = 5) underwent unilateral endobronchial instillation of hydrochloric acid. The PBF distribution was compared between injured and uninjured sides and with that of untreated control animals (n = 6). Changes in lung density after injury were measured using computed tomography (CT). Regional PBF distribution was determined quantitatively in vivo 2 hours after acid instillation by measuring the concentration of [68Ga]-radiolabeled microspheres using positron emission tomography. CT scans revealed increased lung density in areas of acid aspiration. Lung injury was accompanied by impaired gas exchange. Acid aspiration decreased the arterial pressure of oxygen from 157 mmHg [139;165] to 74 mmHg [67;86] at 20 minutes and tended toward restoration to 109 mmHg [69;114] at 110 minutes (P < 0.001). The PBF ratio of the middle region of the injured versus uninjured lungs of the aspiration group (0.86 [0.7;0.9], median [25%;75%]) was significantly lower than the PBF ratio in the left versus right lung of the control group (1.02 [1.0;1.05]; P = 0.016). The PBF pattern 2 hours after aspiration-induced lung injury showed a redistribution of PBF away from injured regions that was likely responsible for the partial recovery from hypoxemia over time. Treatments given intravenously 2 hours after acid-induced lung injury may not preferentially reach the injured lung regions, contrary to what occurs during the first hour of inflammation. Please see related article: http://dx.doi.org/10.1186/s12871-015-0014-z.
登录
查看更多内容
影响因子：
15.9
作者：
FOLKESSON, HG;MATTHAY, MA;BROADDUS, VC
通讯作者：
BROADDUS, VC
影响因子：
8.8
作者：
Carvalho, Nadja C.;Gueldner, Andreas;de Abreu, Marcelo Gama
通讯作者：
de Abreu, Marcelo Gama
影响因子：
8.8
作者：
McAuley, DF;Frank, JA;Matthay, MA
通讯作者：
Matthay, MA
影响因子：
2.2
作者：
Rabinovici, R;Vernick, J;Neville, LF
通讯作者：
Neville, LF
影响因子：
3.3
作者：
CARLILE, PV;HAGAN, SF;GRAY, BA
通讯作者：
GRAY, BA