Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture.
Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture.
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DOI：
10.1126/sciadv.abq2616
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发表时间：
2023-03-29
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
之前的研究强调了非洲基因组是如何被一系列复杂的历史事件塑造的。尽管如此，全基因组数据只从一小部分现代民族语言群体中获得。通过分析来自喀麦隆、刚果共和国、加纳、尼日利亚和苏丹的150多个民族的1333名个体的常染色体遗传变异数据，我们展示了这些国家中以前未被重视的精细遗传结构水平，例如，与喀麦隆西部历史政治相关。通过比较人群之间的遗传变异模式，我们推断，喀麦隆北部和苏丹的许多群体与多个地理上不同的人群有着共同的遗传联系，这可能是长途迁徙的结果。在加纳和尼日利亚，我们推断混合的特征可以追溯到2000多年前，与可能与气候变化有关的环境变化的报告相对应。我们还推断出最近在包括刚果人在内的多个非洲人口中出现的混杂信号，这可能与说班图语的人的扩张有关。历史事件可能在塑造非洲国家人民的基因组方面发挥了可观的作用。
Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language–speaking peoples. Historical events may have played an appreciable role in shaping people’s genomes within African countries.
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影响因子：
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作者：
Browning, Sharon R.;Browning, Brian L.
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