Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning.
Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning.
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DOI：
10.1016/j.biosystems.2012.04.005
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发表时间：
2012-09
期刊：
影响因子：
1.6
通讯作者：
Levin, Michael
中科院分区：
文献类型：
--
作者：
Levin, Michael
在胚胎发育过程中形状的建立，以及对损伤或肿瘤发生的形状的维持，需要不断协调细胞行为以适应宿主生物体的模式化需求。分子细胞生物学和遗传学在理解调节细胞功能的机制方面取得了很大进展。然而，形状的广义理性控制仍然在很大程度上超出了我们目前的能力。重要的指导信号在远距离上起作用，以提供位置信息和其他线索来调节生物体范围内的系统特性，如解剖极性和大小控制。复杂形态发生最好理解为局部细胞相互作用的涌现特性，还是最终目标状态的物理编码地图或模板引导的计算过程的结果？在这里，我回顾了最近的数据和分子机制有关的形态发生领域：大规模的系统的物理特性，已被提出存储图案信息在胚胎发生，再生修复，并最终控制解剖癌症抑制。特别强调内源性生物电信号作为形态发生领域的重要组成部分的作用，我推测新的方法，这些领域的计算建模和控制与合成生物学，再生医学和进化发育生物学的应用。
Establishment of shape during embryonic development, and the maintenance of shape against injury or tumorigenesis, requires constant coordination of cell behaviors toward the patterning needs of the host organism. Molecular cell biology and genetics have made great strides in understanding the mechanisms that regulate cell function. However, generalized rational control of shape is still largely beyond our current capabilities. Significant instructive signals function at long range to provide positional information and other cues to regulate organism-wide systems properties like anatomical polarity and size control. Is complex morphogenesis best understood as the emergent property of local cell interactions, or as the outcome of a computational process that is guided by a physically-encoded map or template of the final goal state? Here I review recent data and molecular mechanisms relevant to morphogenetic fields: large-scale systems of physical properties that have been proposed to store patterning information during embryogenesis, regenerative repair, and cancer suppression that ultimately controls anatomy. Placing special emphasis on the role of endogenous bioelectric signals as an important component of the morphogenetic field, I speculate on novel approaches for the computational modeling and control of these fields with applications to synthetic biology, regenerative medicine, and evolutionary developmental biology.
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DOI：
10.2106/00004623-196143050-00002
发表时间：
1961-01-01
影响因子：
5.3
作者：
BECKER, RO
通讯作者：
BECKER, RO
影响因子：
2.4
作者：
Beloussov, LV;Louchinskaia, NN;Stein, AA
通讯作者：
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影响因子：
3.8
作者：
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DOI：
10.1073/pnas.0606053103
发表时间：
2006-09-05
影响因子：
11.1
作者：
Axelrod, Robert;Axelrod, David E.;Pienta, Kenneth J.
通讯作者：
Pienta, Kenneth J.
影响因子：
5.5
作者：
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通讯作者：
Becchetti, Andrea