Angiotensin-converting Enzyme Inhibitors Decrease the Incidence of Radiation-induced Pneumonitis Among Lung Cancer Patients: A Systematic Review and Meta-analysis.
Angiotensin-converting Enzyme Inhibitors Decrease the Incidence of Radiation-induced Pneumonitis Among Lung Cancer Patients: A Systematic Review and Meta-analysis.
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血管紧张素转换酶抑制剂可降低肺癌患者放射性肺炎的发生率：系统评价和荟萃分析
DOI：
10.7150/jca.24665
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发表时间：
2018
影响因子：
3.9
通讯作者：
Ma H
中科院分区：
文献类型：
--
作者：
Sun F;Sun H;Zheng X;Yang G;Gong N;Zhou H;Wang S;Cheng Z;Ma H
背景资料：在动物模型和临床前研究中，血管紧张素转换酶抑制剂（ACEIs）和血管紧张素受体阻滞剂（ARB）已被证明可减轻辐射诱导的肺损伤。我们的研究旨在评估ACEI或ARB是否降低肺癌患者放射性肺炎（RP）的发生率。方法：检索EMBASE、PubMed和Web of Science数据库中的文献。2000年4月至2016年8月发表的7项研究符合入选标准，共纳入1412例患者。仅分析放疗后12个月内发生2级及以上肺炎的患者。结果如下：服用ACEI的患者发生放射性肺炎的风险低于未服用者（OR = 0.46，95%CI = 0.31-0.67，p < 0.0001）。而ARB的使用并不能降低RP的发生率（OR = 1.42，95%CI = 0.94-2.14，p = 0.10）。老年患者（年龄≥ 70岁）从ACEI中获益更多（OR = 0.12，95%CI = 0.02-0.67，p = 0.02）。此外，吸烟者发生RP的风险低于非吸烟者（OR = 0.49，95%CI = 0.30-0.81，p = 0.005），但性别和使用他汀类药物或NSAID对RP的出现没有影响（分别为p = 0.59，p = 0.70，p = 0.40）。结论：ACE抑制剂可降低肺癌患者症状性RP的发生率。然而，ARB的使用有轻微的RP发展趋势，但不超过统计学显著性。老年患者（年龄≥ 70岁）从ACEI中获益最多。
Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been demonstrated to mitigate radiation-induced lung damage in animal models and preclinical studies. Our study aims to evaluate whether ACEIs or ARBs reduce the incidence of radiation-induced pneumonitis (RP) in lung cancer patients. Methods: Publications were searched from EMBASE, PubMed and Web of Science databases. Seven studies published from April 2000 to August 2016 met inclusion criteria and included 1412 patients in total. Only patients with grade 2 and above pneumonitis within 12 months after radiotherapy were analyzed. Results: Patients taking ACEIs had a lower risk of developing radiation pneumonitis compared with non-users (OR = 0.46, 95%CI = 0.31-0.67, p < 0.0001). While the use of ARBs couldn't reduce the incidence of RP (OR = 1.42, 95%CI = 0.94-2.14, p = 0.10). Elderly patients (age ≥ 70) benefited more from ACEIs (OR = 0.12, 95%CI = 0.02-0.67, p = 0.02). In addition, smokers were found to have a lower risk of developing RP than non-smokers (OR = 0.49, 95%CI = 0.30-0.81, p = 0.005), but sex and the use of statin or NSAID had no influence on the appearance of RP (p = 0.59, p = 0.70, p = 0.40, respectively). Conclusions: ACE inhibitors could decrease the incidence of symptomatic RP among lung cancer patients. However, the use of ARBs has a slight trend to develop RP but not above statistical significance. Elderly patients (age ≥ 70) benefited the most from ACEIs.
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影响因子：
3.6
作者：
Bracci, Stefano;Valeriani, Maurizio;Osti, Mattia F.
通讯作者：
Osti, Mattia F.
DOI：
10.1016/j.jtcvs.2009.12.054
发表时间：
2010-08-01
影响因子：
6
作者：
Crabtree, Traves D.;Denlinger, Chadrick E.;Bradley, Jeffrey D.
通讯作者：
Bradley, Jeffrey D.
DOI：
10.1158/1078-0432.ccr-17-0256
发表时间：
2017-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Liu H;Naxerova K;Pinter M;Incio J;Lee H;Shigeta K;Ho WW;Crain JA;Jacobson A;Michelakos T;Dias-Santos D;Zanconato A;Hong TS;Clark JW;Murphy JE;Ryan DP;Deshpande V;Lillemoe KD;Fernandez-Del Castillo C;Downes M;Evans RM;Michaelson J;Ferrone CR;Boucher Y;Jain RK
通讯作者：
Jain RK
DOI：
10.1016/j.ijrobp.2014.03.048
发表时间：
2014-07-15
影响因子：
7
作者：
Mahmood, Javed;Jelveh, Salomeh;Zaidi, Asif;Doctrow, Susan R.;Medhora, Meetha;Hill, Richard P.
通讯作者：
Hill, Richard P.
DOI：
10.1016/j.ijrobp.2009.07.1743
发表时间：
2009-12-01
影响因子：
7
作者：
Ghosh, Swarajit N.;Zhang, Rong;Fish, Brian L.;Semenenko, Vladmir A.;Li, X. Allen;Moulder, John E.;Jacobs, Elizabeth R.;Medhora, Meetha
通讯作者：
Medhora, Meetha