Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis.
Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis.
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DOI：
10.1016/j.ijrobp.2009.07.1743
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发表时间：
2009-12-01
影响因子：
7
通讯作者：
Medhora, Meetha
中科院分区：
文献类型：
--
作者：
Ghosh, Swarajit N.;Zhang, Rong;Fish, Brian L.;Semenenko, Vladmir A.;Li, X. Allen;Moulder, John E.;Jacobs, Elizabeth R.;Medhora, Meetha
寻找中等剂量胸部放射（10-15戈伊）所致肺炎的缓解措施。未麻醉的WAG/RijCmcr雌性大鼠胸部接受单剂量X射线照射（10、12或15戈伊，1.615戈伊/分钟）。在照射后饮用水给予卡托普利（血管紧张素转换酶抑制剂）或氯沙坦（血管紧张素受体阻断剂）。8周后，通过评估呼吸频率、离体血管反应性和组织病理学，对随机选择的大鼠的肺结构和功能进行评估。对所有动物进行生存分析，计划处死的动物除外。胸部接受10戈伊剂量照射一年后，大鼠的存活率与未接受照射的大鼠没有什么不同。12戈伊照射后45周和15戈伊照射后8-9周，存活率降至50%以下。Captopril（17-56 mg/kg/天）改善了存活率，减少了辐射引起的呼吸频率增加、血管反应性变化和损伤的组织病理学证据。即使在照射后1周开始使用或在5周后停止使用卡托普利，也可防止放射引起的呼吸频率增加。氯沙坦虽然能有效降低死亡率，但在减轻辐射诱导的呼吸频率增加或血管反应性改变方面不如卡托普利有效。在大鼠中，中等胸部剂量的辐射诱发肺炎和发病率。即使在照射后1周开始或暴露后5周停止给药，这些损伤也可被卡托普利减轻。氯沙坦在防止辐射引起的血管反应性变化或呼吸急促方面效果较差。
To find mitigators of pneumonitis induced by moderate doses of thoracic radiation (10–15 Gy). Unanesthetized WAG/RijCmcr female rats received single doses of X-irradiation (10, 12 or 15 Gy at 1.615 Gy/minute) to the thorax. Captopril (an angiotensin converting enzyme inhibitor) or losartan (an angiotensin receptor blocker) was administered in drinking water after irradiation. Pulmonary structure and function were assessed after 8 weeks in randomly selected rats by evaluating breathing rate, ex vivo vascular reactivity and histopathology. Survival analysis was undertaken on all animals except those scheduled for sacrifice. Survival following a dose of 10 Gy to the thorax was not different from unirradiated rats up to one year. Survival decreased to less than 50%, by 45 weeks after 12 Gy and by 8–9 weeks after 15 Gy. Captopril (17–56 mg/kg/day) improved survival and reduced radiation-induced increases in breathing rate, changes in vascular reactivity and histopathological evidence of injury. Radiation-induced increases in breathing rate were prevented even if captopril was started 1 week following irradiation or if it was discontinued after 5 weeks. Losartan, though effective in reducing mortality was not as efficacious as captopril in mitigating radiation-induced increases in breathing rate or altered vasoreactivity. In rats, a moderate thoracic dose of radiation induced pneumonitis and morbidity. These injuries were mitigated by captopril even when it was commenced 1 week after irradiation or if discontinued after 5 weeks following exposure. Losartan was less effective in protecting against radiation-induced changes in vascular reactivity or tachypnea.
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影响因子：
5.7
作者：
Langan, Aimee R.;Khan, Mohammed A.;Hill, Richard P.
通讯作者：
Hill, Richard P.
DOI：
10.1165/ajrcmb.19.1.3145
发表时间：
1998-07-01
影响因子：
6.4
作者：
Zhu, DL;Effros, RM;Jacobs, ER
通讯作者：
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影响因子：
2.6
作者：
Zhang, Rong;Ghosh, Swarajit N.;Medhora, Meetha
通讯作者：
Medhora, Meetha
影响因子：
5.6
作者：
Ignjatovic, T;Tan, FL;Erdös, EG
通讯作者：
Erdös, EG
DOI：
10.1016/j.ijrobp.2008.02.046
发表时间：
2008-07-01
影响因子：
7
作者：
Anscher, Mitchell S.;Thrasher, Bradley;Vujaskovic, Zeljko
通讯作者：
Vujaskovic, Zeljko