The Bam machine: a molecular cooper.

The Bam machine: a molecular cooper.
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BAM机器:分子库珀。

DOI:
10.1016/j.bbamem.2011.08.020
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发表时间:
2012-04
影响因子:
3.4
通讯作者:
Silhavy, Thomas J.
Silhavy, Thomas J.
中科院分区:
生物学3区
文献类型:
--
作者:
Ricci, Dante P.;Silhavy, Thomas J.

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细菌外膜(OM)是一种特殊的生物结构,具有独特的组成,对革兰氏阴性细菌的弹性有重要贡献。由于所有OM成分都是在细胞质溶胶中合成的,因此细胞必须有效地将OM特异性脂质和蛋白质穿过细胞包膜,并将它们稳定地整合到生长的膜中。在这篇综述中,我们讨论了与这些过程相关的挑战,并详细介绍了细胞进化来解决OM生物发生的拓扑问题的优雅解决方案。将特别关注Bam机器,这是一种高度保守的多蛋白复合物,可促进OM β-桶折叠。
The bacterial outer membrane (OM) is an exceptional biological structure with a unique composition that contributes significantly to the resiliency of Gram-negative bacteria. Since all OM components are synthesized in the cytosol, the cell must efficiently transport OM-specific lipids and proteins across the cell envelope and stably integrate them into a growing membrane. In this review, we discuss the challenges associated with these processes and detail the elegant solutions that cells have evolved to address the topological problem of OM biogenesis. Special attention will be paid to the Bam machine, a highly conserved multiprotein complex that facilitates OM β-barrel folding.
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