Characterizing the compression-dependent viscoelastic properties of human hepatic pathologies using dynamic compression testing.
Characterizing the compression-dependent viscoelastic properties of human hepatic pathologies using dynamic compression testing.
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DOI：
10.1088/0031-9155/57/8/2273
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发表时间：
2012-04-21
影响因子：
3.5
通讯作者：
Kliewer MA
中科院分区：
文献类型：
--
作者：
DeWall RJ;Bharat S;Varghese T;Hanson ME;Agni RM;Kliewer MA
弹性成像的最新进展提供了几种能够量化组织弹性（组织的固有特性）的成像模式。该信息对于确定肿瘤边缘很有用，但也可以提供诊断特定肿瘤类型的信息。在这项研究中，我们使用动态压缩测试来量化 16 种人类肝脏原发性和继发性恶性肿瘤及其手术切除后获得的相应背景组织的粘弹性特性。还测试了另外两个背景。对背景组织的分析表明，F4 级纤维化肝组织比 F0 级组织明显更硬，模量对比度为 4:1。脂肪肝组织比正常肝组织稍硬，但不明显。原发性肝细胞癌的肿瘤与背景储能模量对比度约为1:1，并且对比度随着背景组织纤维化程度的增加而降低。斜坡测试表明背景硬度比恶性组织增加得更快。相反，继发性肿瘤通常比周围背景硬得多，结肠转移瘤的肿瘤与背景对比度为 10:1，胆管癌的肿瘤与背景对比度为 10:1。斜坡测试表明，结肠转移瘤的硬化速度比相应的背景更快。这些数据提供了对特定肿瘤类型机械特性的深入了解，随着定量刚度成像的使用增加，这可能会被证明是有益的。
Recent advances in elastography have provided several imaging modalities capable of quantifying the elasticity of tissue, an intrinsic tissue property. This information is useful for determining tumour margins but may also provide information to diagnose specific tumour types. In this study, we used dynamic compression testing to quantify the viscoelastic properties of 16 human hepatic primary and secondary malignancies and their corresponding background tissue obtained following surgical resection. Two additional backgrounds were also tested. An analysis of the background tissue showed that F4-graded fibrotic liver tissue was significantly stiffer than F0-graded tissue, with a modulus contrast of 4:1. Steatotic liver tissue was slightly stiffer than normal liver tissue, but not significantly so. The tumour-to-background storage modulus contrast of hepatocellular carcinomas, a primary tumour, was approximately 1:1, and the contrast decreased with increasing fibrosis grade of the background tissue. Ramp testing showed that the background stiffness increased faster than the malignant tissue. Conversely, secondary tumours were typically much stiffer than the surrounding background, with a tumour-to-background contrast of 10:1 for colon metastases and 10:1 for cholangiocarcinomas. Ramp testing showed that colon metastases stiffened faster than their corresponding background. These data have provided insights into the mechanical properties of specific tumour types, which may prove beneficial as the use of quantitative stiffness imaging increases.
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影响因子：
10.6
作者：
DeWall RJ;Varghese T;Madsen EL
通讯作者：
Madsen EL
影响因子：
3.8
作者：
Bharat, Shyam;Varghese, Tomy;Zagzebski, James A.
通讯作者：
Zagzebski, James A.
影响因子：
2.9
作者：
Fahey, Brian J.;Nelson, Rendon C.;Trahey, Gregg E.
通讯作者：
Trahey, Gregg E.
影响因子：
5.2
作者：
Kusaka, K;Harihara, Y;Omata, S
通讯作者：
Omata, S
影响因子：
1.1
作者：
Chatelin, Simon;Oudry, Jennifer;Willinger, Remy
通讯作者：
Willinger, Remy