Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study.
Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study.
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DOI：
10.1186/s10194-016-0667-0
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Tedeschi G
中科院分区：
文献类型：
--
作者：
Santangelo G;Russo A;Trojano L;Falco F;Marcuccio L;Siciliano M;Conte F;Garramone F;Tessitore A;Tedeschi G
偏头痛患者认知功能障碍和心理症状的发生，以及它们之间的相互关系仍然存在争议。本研究的目的是描述无先兆药物初治偏头痛（MwoA）患者的认知特征和心理症状（即抑郁、焦虑和冷漠）。72名连续MwoA患者，转诊到意大利大学头痛诊所和72名健康受试者（HC）入组。患者在无发作期和HC完成蒙特利尔认知评估（莫卡），贝克抑郁量表-II（BDI-II），自我版本的冷漠评价量表（AES-S）和状态和特质焦虑量表（STAI-Y-1和2）。记录疾病严重程度的临床参数（即疾病持续时间、每月偏头痛发作次数、偏头痛发作期间的平均疼痛强度、偏头痛残疾和对日常生活的影响）。尽管MwoA患者接受莫卡治疗的表现高于意大利截止阈值，（<15.5）提示存在认知障碍，MwoA患者在总莫卡量表上的得分显著低于HC（22.3 ± 2.7对25.4 ± 2.3）和对它的注意（4.9 ± 1.1 vs 5.6 ± 0.7），记忆（1.8 ± 1.4 vs 3.1 ± 1.3）、视觉空间（3.2 ± 0.9 vs 3.6 ± 0.6）和执行子量表（2.6 ± 1.1 vs 3.1 ± 0.8）。此外，我们还观察到莫卡执行领域子评分与攻击相关残疾评分（MIDAS）之间存在显著相关性。在行为特征方面，MwoA患者中抑郁症状（4.2%）、高度状态焦虑和特质焦虑（分别为13.9%和9.7%）和冷漠（11.1%）的比例与HC相似。行为症状与认知能力和临床参数无显著相关性。药物初治MwoA患者的特点是轻微的认知功能障碍和低比例的行为症状。研究结果支持了在MwoA患者中寻找亚临床认知障碍的重要性，这些患者值得随访，以验证他们是否会随着时间的推移发展出临床相关的疾病。
The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïve migraine without aura (MwoA) patients. Seventy-two consecutive MwoA patients, referred to the Italian University Headache Clinic and 72 healthy subjects (HCs) were enrolled. Patients, during an attack-free period, and HCs completed Montreal Cognitive Assessment (MoCA), Beck Depression Inventory-II (BDI-II), Self-version of Apathy Evaluation Scale (AES-S) and State and Trait Anxiety Inventory (STAI-Y-1 and 2). Clinical parameters of disease severity (i.e. disease duration, migraine attacks per month, mean pain intensity during migraine attacks, migraine disability and impact on daily life) were recorded. Although performance of MwoA patients on MoCA was above Italian cut-off threshold (<15.5) suggesting presence of cognitive impairment, MwoA patients achieved significantly lower scores than HCs on total MoCA scale (22.3 ± 2.7 versus 25.4 ± 2.3) and on its attention (4.9 ± 1.1 versus 5.6 ± 0.7), memory (1.8 ± 1.4 versus 3.1 ± 1.3), visuospatial (3.2 ± 0.9 versus 3.6 ± 0.6) and executive subscales (2.6 ± 1.1 versus 3.1 ± 0.8). In addition, we observed significant correlations between MoCA executive domain subscore and the attack-related disability score (MIDAS). As for behavioral profile, the percentage of depressive symptoms (4.2 %), high state and trait anxiety (13.9 and 9.7 %, respectively), and apathy (11.1 %) in MwoA patients were similar to that of HCs. No significant associations of behavioural symptoms with cognitive performance and clinical parameters were found. Drug-naïve MwoA patients are characterized by subtle cognitive dysfunctions and low percentage of behavioural symptoms. The results support the importance of searching for subclinical cognitive disturbances in patients with MwoA, who deserve to be followed-up to verify whether they develop clinically relevant disorders over time.
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影响因子：
--
作者：
HOOKER, WD;RASKIN, NH
通讯作者：
RASKIN, NH
影响因子：
5
作者：
Burch, Rebecca C.;Loder, Stephen;Smitherman, Todd A.
通讯作者：
Smitherman, Todd A.
DOI：
10.1186/s10194-016-0649-2
发表时间：
2016
期刊：
The journal of headache and pain
影响因子：
--
作者：
Lampl C;Thomas H;Tassorelli C;Katsarava Z;Laínez JM;Lantéri-Minet M;Rastenyte D;Ruiz de la Torre E;Stovner LJ;Andrée C;Steiner TJ
通讯作者：
Steiner TJ
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF
影响因子：
4.9
作者：
Pearson, AJ;Chronicle, EP;Bruce, LAM
通讯作者：
Bruce, LAM