Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases.
Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases.
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DOI：
10.1007/s00395-021-00889-1
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发表时间：
2021-08-14
影响因子：
9.5
通讯作者：
Pauklin S
中科院分区：
文献类型：
--
作者：
Feng Y;Huang W;Paul C;Liu X;Sadayappan S;Wang Y;Pauklin S
真核细胞中的代谢功能和能量产生由线粒体调节，线粒体因其调节细胞内稳态而被认为是真核细胞的细胞内“发电站”。线粒体功能不仅在正常发育和生理过程中很重要，而且在各种人类病理学中也很重要，包括心脏病。线粒体类核在代谢重编程中的作用是心血管医学领域的一个新兴课题。这篇综述描述了线粒体类核的线性/3D结构（例如，类核的高度组织化的蛋白质-DNA结构）以及它如何受到各种因素的调节，如非编码RNA及其相关的R环，用于心脏疾病中的代谢重编程。此外，我们强调了许多目前尚未解决的问题，心脏代谢方面的双向信号的线粒体类核和3D染色质结构的核。特别是，我们探索新的技术来解剖线粒体类核的3D结构，并提出新的见解线粒体逆行信号，以及它如何调节线粒体疾病的核（3D）染色质结构。
Metabolic function and energy production in eukaryotic cells are regulated by mitochondria, which have been recognized as the intracellular ‘powerhouses’ of eukaryotic cells for their regulation of cellular homeostasis. Mitochondrial function is important not only in normal developmental and physiological processes, but also in a variety of human pathologies, including cardiac diseases. An emerging topic in the field of cardiovascular medicine is the implication of mitochondrial nucleoid for metabolic reprogramming. This review describes the linear/3D architecture of the mitochondrial nucleoid (e.g., highly organized protein-DNA structure of nucleoid) and how it is regulated by a variety of factors, such as noncoding RNA and its associated R-loop, for metabolic reprogramming in cardiac diseases. In addition, we highlight many of the presently unsolved questions regarding cardiac metabolism in terms of bidirectional signaling of mitochondrial nucleoid and 3D chromatin structure in the nucleus. In particular, we explore novel techniques to dissect the 3D structure of mitochondrial nucleoid and propose new insights into the mitochondrial retrograde signaling, and how it regulates the nuclear (3D) chromatin structures in mitochondrial diseases.
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影响因子：
29
作者：
Camara, Yolanda;Asin-Cayuela, Jorge;Larsson, Nils-Goran
通讯作者：
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影响因子：
9.8
作者：
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3.5
作者：
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Capaldi, RA
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影响因子：
64.8
作者：
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影响因子：
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作者：
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