Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma.
Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma.
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DOI：
10.1136/ard.2009.127621
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发表时间：
2011-01
影响因子：
27.4
通讯作者：
Medsger TA Jr
中科院分区：
文献类型：
--
作者：
Domsic RT;Rodriguez-Reyna T;Lucas M;Fertig N;Medsger TA Jr
研究皮肤厚度进展率（STPR）与死亡率的关系，并作为弥漫性皮肤系统性硬化症（SSc）患者初始队列中未来内脏器官受累的预测因子。在1980年至2005年首次出现皮肤增厚证据的2年内在匹兹堡大学评估的16岁以上弥漫性皮肤SSc患者符合条件。作者计算了这些患者的STPR，并使用logistic回归分析了该变量与早期内脏器官受累和短期死亡率的关系。826例患者被纳入分析。快速STPR患者在首次匹兹堡评估后1年和2年的短期生存率显著降低（p=0.002）。快速STPR的患者更有可能在随访1-2年内发生肾危象。研究发现，快速STPR是首次评估后2年内死亡率（OR 1.72; 95%CI 1.13 - 2.62; p=0.01）和“肾危象”（OR 2.05，95%CI 1.10 - 3.85; p=0.02）的独立预测因子。STPR是一个简单的措施，在初步评估时进行，以确定那些弥漫性皮肤SSc患者的死亡风险增加，并在随后的2年内发生肾危象。
To examine the association of skin thickness progression rate (STPR) with mortality, and as a predictor of future internal organ involvement in an inception cohort of diffuse cutaneous systemic sclerosis (SSc) patients. Diffuse cutaneous SSc patients older than 16 years of age evaluated at the University of Pittsburgh within 2 years of the first evidence of skin thickening between 1980 and 2005 were eligible. The authors calculated the STPR on these patients, and examined the relationship of this variable to the development of early internal organ involvement and short-term mortality using logistic regression. 826 patients were included in the analysis. Patients with a rapid STPR experienced significantly reduced short-term survival at 1 and 2 years from the time of first Pittsburgh evaluation (p=0.002). Patients with a rapid STPR were more likely to develop renal crisis within 1–2 years of follow-up. Rapid STPR was found to be an independent predictor of both mortality (OR 1.72; 95% CI 1.13 to 2.62; p=0.01) and ‘renal crisis’ (OR 2.05, 95% CI 1.10 to 3.85; p=0.02) within 2 years from first evaluation. The STPR is an easy measure to perform at the time of initial evaluation for identifying those diffuse cutaneous SSc patients who are at increased risk of mortality and the development of renal crisis during the following 2 years.
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影响因子：
3.4
作者：
Nagy, Z;Czirjak, L
通讯作者：
Czirjak, L
影响因子：
--
作者：
Shand, Lynne;Lunt, Mark;Denton, Christopher P.
通讯作者：
Denton, Christopher P.
影响因子：
27.4
作者：
Hesselstrand, R;Scheja, A;Åkesson, A
通讯作者：
Åkesson, A
影响因子：
1.6
作者：
Ferri, C;Valentini, G;Tirri, G
通讯作者：
Tirri, G
影响因子：
27.4
作者：
Czirjak, L.;Kumanovics, G.;Szucs, G.
通讯作者：
Szucs, G.