Common themes in the design and function of bacterial effectors.

Common themes in the design and function of bacterial effectors.
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细菌效应器设计和功能的常见主题。

DOI:
10.1016/j.chom.2009.04.008
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发表时间:
2009-06-18
影响因子:
30.3
通讯作者:
Galan, Jorge E.
Galan, Jorge E.
中科院分区:
医学1区
文献类型:
--
作者:
Galan, Jorge E.

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许多病原菌的生物学核心是许多专门的机器,称为III型,IV型或VI型蛋白质分泌系统。这些机器已经特别进化为将细菌“效应器”蛋白递送到宿主细胞中,具有调节多种细胞功能的能力。许多效应蛋白的生化活性的鉴定,再加上更好地了解其潜在的贡献,发病机制,揭示了这些显着的细菌蛋白的进化设计和功能的共同主题。
Central to the biology of many pathogenic bacteria are a number of specialized machines, known as type III, type IV or type VI protein secretion systems. These machines have specifically evolved to deliver bacterial “effector” proteins into host cells with the capacity to modulate a variety of cellular functions. The identification of the biochemical activities of many effector proteins, coupled with a better understanding of their potential contribution to pathogenesis, have revealed common themes in the evolutionary design and function of these remarkable bacterial proteins.
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