Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke.
Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke.
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DOI：
10.1016/j.jstrokecerebrovasdis.2017.06.042
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
SIREN Team
中科院分区：
文献类型：
--
作者：
Owolabi M;Ogbole G;Akinyemi R;Salaam K;Akpa O;Mongkolwat P;Omisore A;Agunloye A;Efidi R;Odo J;Makanjuola A;Akpalu A;Sarfo F;Owolabi L;Obiako R;Wahab K;Sanya E;Adebayo P;Komolafe M;Adeoye AM;Fawale MB;Akinyemi J;Osaigbovo G;Sunmonu T;Olowoyo P;Chukwuonye I;Obiabo Y;Ibinaiye P;Dambatta A;Mensah Y;Abdul S;Olabinri E;Ikubor J;Oyinloye O;Odunlami F;Melikam E;Saulson R;Kolo P;Ogunniyi A;Ovbiagele B;SIREN Team
ClearCanvas 丰富的中风表型分析软件 (ACCESS) 上的 AIM 是一种新颖的独立计算机软件应用程序，允许创建简单的标准化注释来报告所有中风类型的大脑图像。我们开发了 ACCESS 应用程序，并在中风调查研究和教育网络 (SIREN) 研究中确定了其评估者间和评估者内的可靠性，以评估其对多中心研究的适用性。来自 5 个 SIREN 站点的 100 份随机选择的中风成像报告由四名经过培训的独立评估者重新评估，以确定 ACCESS（12.0 版）软件中风表型分析的评估者间可靠性。为了确定评估者内部的可靠性，六名评估者在一个月的间隔后审查了他们之前报告的相同案例。缺血性中风使用牛津郡社区中风项目 (OCSP)、TOAST 和 ASCO 协议进行分类，而出血性中风使用 ACCESS 中的 SMASH-U 协议进行分类。评估者之间的一致性是通过 Cohen 的 kappa 统计数据来衡量的。对于原发性卒中类型，评估者间一致性为 0.98 (95%CI: 0.94–1.00)，而评估者内部一致性为 1.00 (95%CI: 1.00)。对于 OCSP 亚型，部分前循环梗死 (PACI) 的评估者间一致性为 0.97 (95%CI: 0.92–1.00)，完全前循环梗死 (TACI) 的评估者间一致性为 0.92 (95%CI: 0.76–1.00)，腔隙性梗死 (LACI) 和后循环梗死的评估者间一致性非常好（POCI）。 TOAST 亚型的评估者内部一致性为 0.97 (0.90–1.00)，而评估者间一致性为 0.93 (95% CI: 0.84–1.00)。 ASCO 亚型的评估者间一致性范围为 0.78（心脏栓塞）至 0.91（大动脉粥样硬化），SMASH-U 亚型的评估者间一致性为 0.80（95% CI：0.56-1.00）。 ACCESS 应用程序有助于多个研究人员对中风亚型进行一致且可重复的分类，使其适合临床和多中心研究。
AIM on ClearCanvas Enriched Stroke- phenotyping Software (ACCESS) is a novel standalone computer software application that allows creation of simple standardized annotations for reporting brain images of all stroke types. We developed the ACCESS application and determined its inter-rater and intra-rater reliability in the Stroke Investigative Research and Educational Network (SIREN) study to assess its suitability for multicenter studies. One hundred randomly selected stroke imaging reports from five SIREN sites were reevaluated by four trained independent raters to determine inter-rater reliability of ACCESS (version 12.0) software for stroke phenotyping. To determine intra-rater reliability, six raters reviewed the same cases previously reported by them after a month interval. Ischemic stroke was classified using the Oxfordshire Community Stroke Project (OCSP), TOAST and ASCO protocols, while hemorrhagic stroke was classified using the SMASH-U protocol in ACCESS. Agreement among raters was measured with Cohen’s kappa statistics. For primary stroke type, inter-rater agreement was 0.98 (95%CI: 0.94–1.00) while intra-rater agreement was 1.00 (95%CI: 1.00). For OCSP subtypes, inter-rater agreement was 0.97 (95%CI: 0.92–1.00) for the Partial Anterior Circulation Infarcts (PACI), 0.92 (95%CI: 0.76–1.00) for the Total Anterior Circulation Infarcts(TACI) and excellent for both Lacunar Infarct (LACI) and Posterior Circulation Infarcts (POCI). Intra-rater agreement was 0.97 (0.90–1.00) while inter-rater agreement was 0.93 (95%CI: 0.84–1.00) for TOAST subtypes. Inter-rater agreement ranged between 0.78 (cardioembolic) to 0.91 (large artery atherosclerotic) for ASCO subtypes and was 0.80 (95%CI: 0.56–1.00) for SMASH-U subtypes. The ACCESS application facilitates concordant and reproducible classification of stroke subtypes by multiple investigators, making it suitable for clinical and multicenter research.
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影响因子：
8.3
作者：
Meretoja, Atte;Strbian, Daniel;Tatlisumak, Turgut
通讯作者：
Tatlisumak, Turgut
影响因子：
9.9
作者：
Arsava, E. M.;Ballabio, E.;Ay, H.
通讯作者：
Ay, H.
影响因子：
168.9
作者：
BAMFORD, J
通讯作者：
BAMFORD, J
影响因子：
5.5
作者：
Mongkolwat, Pattanasak;Channin, David S.;Rubin, Daniel L.
通讯作者：
Rubin, Daniel L.
影响因子：
0.7
作者：
Akinyemi RO;Ovbiagele B;Akpalu A;Jenkins C;Sagoe K;Owolabi L;Sarfo F;Obiako R;Gebreziabher M;Melikam E;Warth S;Arulogun O;Lackland D;Ogunniyi A;Tiwari H;Kalaria RN;Arnett D;Owolabi MO;SIREN Investigators as Members of the H3Africa Consortium
通讯作者：
SIREN Investigators as Members of the H3Africa Consortium