Amphibian myiasis. Blowfly larvae (Lucilia bufonivora, Diptera: Calliphoridae) coping with the poisonous skin secretion of the common toad (Bufo bufo)

Amphibian myiasis. Blowfly larvae (Lucilia bufonivora, Diptera: Calliphoridae) coping with the poisonous skin secretion of the common toad (Bufo bufo)
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两栖类蝇蛆病 绿头蝇幼虫(Lucilia bufonivora,双翅目:Calliphoridae)应对普通蟾蜍(Bufo bufo)有毒的皮肤分泌物

DOI:
10.1007/s00049-014-0157-2
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发表时间:
2014
期刊:
影响因子:
1.8
通讯作者:
Dobler
Dobler
中科院分区:
环境科学与生态学3区
文献类型:
--
作者:
Petschenka;Pogoda;Toennes;Amendl;Dobler

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蟾蜍绿蝇对蟾蜍具有高度的寄主专一性,其皮肤分泌物主要由蟾蜍二烯内酯组成。这些毒素是Na+,K+-ATP酶的有效阻断剂,Na+,K+-ATP酶是动物许多生理过程所必需的酶。虽然在苍蝇幼虫中发现了普通蟾蜍(Bufo bufo)毒素,但在蛹和空蛹中发现的微量毒素很少,而成年苍蝇完全没有这些有毒化合物。当多面手食尸性绿头苍蝇(L。绢毛丽蝇(Calliphora vicina)以蟾蜍尸体为食。Na+,K+-ATP酶基因的分析表明,在其他系统中,在已知介导蟾蜍二烯内酯抗性的位置没有氨基酸取代。替代的抗性机制,如化合物的有效排泄,可能使苍蝇能够使用这种有毒的食物来源。
The blowflyLucilia bufonivorashows high host specificity for toads despite the host’s toxic skin secretion, which consists mainly of bufadienolides. These toxins are effective blockers of the Na+, K+-ATPase, an enzyme that is essential for many physiological processes in animals. Whereas common toad (Bufo bufo) toxins were identified in the larvae of the fly, few toxins were found in the pupae and empty puparia as trace amounts, while adult flies were entirely free of these toxic compounds. Similar results were obtained when larvae of generalist necrophagous blowflies (L. sericata, Calliphora vicina) fed on toad carcasses. Analysis of the Na+, K+-ATPase gene revealed no amino acid substitution at positions known to mediate resistance to bufadienolides in other systems. Alternative mechanisms of resistance such as efficient excretion of the compounds may enable the flies to use this poisonous food source.
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