Calcitonin gene-related peptide: key regulator of cutaneous immunity.
Calcitonin gene-related peptide: key regulator of cutaneous immunity.
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DOI：
10.1111/apha.12442
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Ding W
中科院分区：
文献类型：
--
作者：
Granstein RD;Wagner JA;Stohl LL;Ding W
降钙素基因相关肽（CGRP）被视为一种神经肽和血管扩张剂。然而，CGRP 更适合被认为是一种多效性信号分子。事实上，CGRP 对皮肤内的免疫和炎症过程具有关键的调节功能。含有 CGRP 的神经与表皮 LC 密切相关，CGRP 对朗格汉斯细胞抗原呈递能力具有深远的调节作用。当 LC 在体外暴露于 CGRP 时，至少在某些情况下，它们呈递抗原以在体内启动幼鼠或引发迟发型超敏反应的能力受到抑制。皮内施用 CGRP 可抑制注射部位对 Th1 主导型半抗原的免疫力的获得，同时增强对 Th2 主导型半抗原的免疫力，尽管这些实验中活性的细胞目标仍不清楚。尽管 CGRP 可以是促炎剂，但一些研究表明，施用 CGRP 可以抑制体内炎症刺激引起的炎症。在这方面，CGRP 抑制受刺激的内皮细胞释放某些趋化因子。这可能与生理相关，因为皮肤血管受感觉神经支配。令人兴奋的新研究表明 CGRP 在银屑病发病机制中发挥着重要作用，最引人注目的是 CGRP 抑制 LC 将人类免疫缺陷病毒 1 传播至 T 淋巴细胞的能力。更全面地了解 CGRP 在皮肤免疫系统中的作用可能会带来治疗免疫介导的皮肤疾病的新方法。
Calcitonin gene-related peptide (CGRP) has been viewed as a neuropeptide and vasodilator. However, CGRP is more appropriately thought of as a pleiotropic signaling molecule. Indeed, CGRP has key regulatory functions on immune and inflammatory processes within the skin. CGRP-containing nerves are intimately associated with epidermal LCs and CGRP has profound regulatory effects on Langerhans cell antigen-presenting capability. When LCs are exposed to CGRP in vitro, their ability to present antigen for in vivo priming of naïve mice or elicitation of delayed-type hypersensitivity is inhibited in at least some situations. Administration of CGRP intradermally inhibits acquisition of immunity to Th1-dominant haptens applied to the injected site while augmenting immunity to Th2-dominant haptens, although the cellular targets of activity in these experiments remains unclear. Although CGRP can be a pro-inflammatory agent, several studies have demonstrated that administration of CGRP can inhibit the elicitation of inflammation by inflammatory stimuli in vivo. In this regard, CGRP inhibits the release of certain chemokines by stimulated endothelial cells. This is likely to be physiologically relevant since cutaneous blood vessels are innervated by sensory nerves. Exciting new studies suggest a significant role for CGRP in the pathogenesis of psoriasis and, most strikingly, that CGRP inhibit the ability of LCs to transmit the human immunodeficiency virus 1 to T lymphocytes. A more complete understanding of the role of CGRP in the skin immune system may lead to new and novel approaches for the therapy of immune mediated skin disorders.
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影响因子：
3.1
作者：
Gomes, RN;Castro-Faria-Neto, HC;Bozza, MT
通讯作者：
Bozza, MT
影响因子：
6.5
作者：
Ding, Wanhong;Wagner, John A.;Granstein, Richard D.
通讯作者：
Granstein, Richard D.
DOI：
10.1152/ajpgi.00528.2003
发表时间：
2004-07-01
影响因子：
4.5
作者：
De Jonge, F;De Laet, A;Kroese, ABA
通讯作者：
Kroese, ABA
DOI：
10.4049/jimmunol.181.9.6020
发表时间：
2008-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ding W;Stohl LL;Wagner JA;Granstein RD
通讯作者：
Granstein RD
影响因子：
6.1
作者：
Clementi, Giuseppe;Caruso, Antonina;Amico-Roxas, Matilde
通讯作者：
Amico-Roxas, Matilde