High-Fidelity Measures of Whole-Brain Functional Connectivity and White Matter Integrity Mediate Relationships between Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.
High-Fidelity Measures of Whole-Brain Functional Connectivity and White Matter Integrity Mediate Relationships between Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.
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DOI：
10.1089/neu.2017.5428
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发表时间：
2018-03-01
影响因子：
4.2
通讯作者：
Nelson SM
中科院分区：
文献类型：
--
作者：
Gordon EM;Scheibel RS;Zambrano-Vazquez L;Jia-Richards M;May GJ;Meyer EC;Nelson SM
创伤性脑损伤（TBI）会破坏大脑沟通，增加创伤后应激障碍（PTSD）的风险。然而，TBI相关的大脑通讯中断导致PTSD风险的机制尚未在人类中成功阐明。这可能部分是因为功能性磁共振成像（fMRI），测量功能性大脑通信的最常见技术，对于表征个体患者是不可靠的。然而，这种不可靠性可以通过足够的个体内数据来克服。在这里，我们通过收集26名美国退伍军人每人约3.5小时的静息状态fMRI和DTI数据，研究是否可以观察到TBI，结构和功能性脑连接以及PTSD严重程度之间的关系。我们观察到TBI病史与全脑静息状态功能连接性（RSFC）降低相关，而终生TBI次数与全脑各向异性分数（FA）降低相关。RSFC和FA都解释了PTSD严重程度的独立变量，RSFC介导了TBI-PTSD关系。最后，我们发现，大量的个人数据产生高度可靠的RSFC措施，TBI，RSFC/FA，和PTSD之间的关系不能观察到典型的数据量。这些结果证明了TBI，大脑连接和PTSD严重程度之间的联系，并说明了使用高数据fMRI扫描精确表征个体患者的必要性。
Traumatic brain injury (TBI) disrupts brain communication and increases risk for posttraumatic stress disorder (PTSD). However, mechanisms by which TBI-related disruption of brain communication confers PTSD risk have not been successfully elucidated in humans. This may be in part because functional magnetic resonance imaging (fMRI), the most common technique for measuring functional brain communication, is unreliable for characterizing individual patients. However, this unreliability can be overcome with sufficient within-individual data. Here, we examined whether relationships could be observed between TBI, structural and functional brain connectivity, and PTSD severity by collecting ~3.5 hours of resting-state fMRI and DTI data in each of 26 US military veterans. We observed that a TBI history was associated with decreased whole-brain resting-state functional connectivity (RSFC), while the number of lifetime TBIs was associated with reduced whole-brain fractional anisotropy (FA). Both RSFC and FA explained independent variance in PTSD severity, with RSFC mediating the TBI-PTSD relationship. Finally, we showed that large amounts of per-individual data produced highly reliable RSFC measures, and that relationships between TBI, RSFC/FA, and PTSD could not be observed with typical data quantities. These results demonstrate links between TBI, brain connectivity, and PTSD severity, and illustrate the need for precise characterization of individual patients using high-data fMRI scanning.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
2.9
作者：
Bharath RD;Munivenkatappa A;Gohel S;Panda R;Saini J;Rajeswaran J;Shukla D;Bhagavatula ID;Biswal BB
通讯作者：
Biswal BB
影响因子：
5.3
作者：
Bonnelle, Valerie;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
2.4
作者：
Bazarian, Jeffrey J.;Donnelly, Kerry;Zhong, Jianhui
通讯作者：
Zhong, Jianhui