Clinical Relevance and Management of "Pre-Interstitial Lung Disease".

Clinical Relevance and Management of "Pre-Interstitial Lung Disease".
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DOI:
10.1016/j.ccm.2021.03.009
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发表时间:
2021-06
影响因子:
5.7
通讯作者:
Putman RK
Putman RK
中科院分区:
医学3区
文献类型:
--
作者:
Podolanczuk AJ;Putman RK

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导致间质性肺病(ILD)的细胞水平变化可能需要数年时间才能在临床上表现出来,并被称为临床前ILD偶然发现的间质性肺异常(ILA)越来越多地在胸部CT中被识别出来,作为肺癌筛查的一部分和用于其他目的许多发现患有ILA的个体将进展为临床显着的ILD ILA与更大的死亡风险独立相关,肺功能下降和偶发肺癌目前的管理建议集中于通过临床和放射学特征的组合来识别具有进展高风险的ILA个体。目前的共识建议集中于对具有ILA和高风险特征的个体进行积极监测。
Cellular level changes that lead to interstitial lung disease (ILD) may take years to become clinically apparent and have been termed preclinical ILD Incidentally identified interstitial lung abnormalities (ILA) are increasingly being recognized on chest CTs done as part of lung cancer screening and for other purposes Many individuals found to have ILA will progress to clinically significant ILD ILA are independently associated with greater risk of death, lung function decline and incident lung cancer Current management recommendations focus on identifying individuals with ILA at high risk of progression, through a combination of clinical and radiological features Current consensus recommendations focus on active monitoring of individuals with ILA and high-risk features.
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