Amygdala-prefrontal interactions in (mal)adaptive learning.
Amygdala-prefrontal interactions in (mal)adaptive learning.
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DOI：
10.1016/j.tins.2014.12.007
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发表时间：
2015-03
影响因子：
15.9
通讯作者：
Paz R
中科院分区：
文献类型：
--
作者：
Likhtik E;Paz R
对焦虑症背后的神经生物学机制的研究是由将焦虑视为适应不良学习的学习模型所塑造的。巴甫洛夫条件作用和消退对于定义可以解释焦虑症症状的学习阶段特别有影响力。最近，杏仁核基底外侧复合体（BLA）和内侧前额叶皮层（mPFC）之间的动态和任务相关的通信已成为成功评估威胁和安全的关键方面。回顾了适应性学习的编码、表达和消退过程中 mPFCBLA 回路内神经信号传导的持续模式。 mPFC-BLA 相互作用缺陷可能导致普遍恐惧的机制在习得性焦虑和先天性焦虑中进行了讨论。强调具有跨物种有效性的研究结果。
The study of neurobiological mechanisms underlying anxiety disorders has been shaped by learning models that frame anxiety as maladaptive learning. Pavlovian conditioning and extinction are particularly influential in defining learning stages that can account for symptoms of anxiety disorders. Recently, dynamic and task related communication between the basolateral complex of the amygdala (BLA) and the medial prefrontal cortex (mPFC) has emerged as a crucial aspect of successful evaluation of threat and safety. Ongoing patterns of neural signaling within the mPFCBLA circuit during encoding, expression and extinction of adaptive learning are reviewed. The mechanisms whereby deficient mPFC-BLA interactions can lead to generalized fear are discussed in learned and innate anxiety. Findings with crossspecies validity are emphasized.
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影响因子：
13.9
作者：
Fenno L;Yizhar O;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
3
作者：
Criado-Marrero M;Santini E;Porter JT
通讯作者：
Porter JT
影响因子：
16.2
作者：
Duvarci S;Pare D
通讯作者：
Pare D
影响因子：
2
作者：
Cole, Sindy;Powell, Daniel J.;Petrovich, Gorica D.
通讯作者：
Petrovich, Gorica D.
DOI：
10.1523/jneurosci.4715-11.2011
发表时间：
2011-12-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bryden DW;Johnson EE;Tobia SC;Kashtelyan V;Roesch MR
通讯作者：
Roesch MR