Shining the light on eating disorders, incidence, prognosis and profiling of patients in primary and secondary care: national data linkage study.
Shining the light on eating disorders, incidence, prognosis and profiling of patients in primary and secondary care: national data linkage study.
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DOI：
10.1192/bjp.2019.153
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Tan JOA
中科院分区：
文献类型：
--
作者：
Demmler JC;Brophy ST;Marchant A;John A;Tan JOA
诊断饮食失调可能很困难，尽管发病率和死亡率很高，但很少有人接受专家服务。从发病率、合并症和生存率方面检查人群饮食失调的负担。我们使用安全匿名信息链接 (SAIL) 数据库中英国威尔士全科医生和入院的链接电子健康记录来调查新的饮食失调诊断的发生率。我们检查了病例和对照诊断前 2 年和诊断后 3 年的共病诊断频率和处方药物，并进行了生存分析。 1990年至2017年间，共有15 558人被诊断患有饮食失调。2003/2004年发病率达到峰值，达到每10万人24人。饮食失调的人表现出较高水平的其他精神障碍（比值比 4.32，95% CI 4.01–4.66）以及发病率和死亡率的外部原因（比值比 2.92，95% CI 2.44–3.50）。他们在诊断前服用中枢神经系统药物（比值比 3.15，95% CI 2.97–3.33）、胃肠道药物（比值比 2.61，95% CI 2.45–2.79）和饮食药物（比值比 2.42，95% CI 2.24–2.62）的处方较多。这些多余的诊断和处方在诊断后仍保留 3 年。与某些饮食失调的对照组相比，死亡率有所上升，特别是患有神经性厌食症的女性。人群中确诊的饮食失调的发病率相对较低，但个人的发病率和死亡率存在重大的长期负担。
Diagnosing eating disorders can be difficult and few people with the disorder receive specialist services despite the associated high morbidity and mortality. To examine the burden of eating disorders in the population in terms of incidence, comorbidities and survival. We used linked electronic health records from general practitioner and hospital admissions in Wales, UK within the Secure Anonymised Information Linkage (SAIL) databank to investigate the incidence of new eating disorder diagnoses. We examined the frequency of comorbid diagnoses and prescribed medications in cases and controls in the 2 years before and 3 years after diagnosis, and performed a survival analysis. A total of 15 558 people were diagnosed with eating disorders between 1990 and 2017. The incidence peaked at 24 per 100 000 people in 2003/04. People with eating disorders showed higher levels of other mental disorders (odds ratio 4.32, 95% CI 4.01–4.66) and external causes of morbidity and mortality (odds ratio 2.92, 95% CI 2.44–3.50). They had greater prescription of central nervous system drugs (odds ratio 3.15, 95% CI 2.97–3.33), gastrointestinal drugs (odds ratio 2.61, 95% CI 2.45–2.79) and dietetic drugs (odds ratio 2.42, 95% CI 2.24–2.62) before diagnosis. These excess diagnoses and prescriptions remained 3 years after diagnosis. Mortality was raised compared with controls for some eating disorders, particularly in females with anorexia nervosa. Incidence of diagnosed eating disorders is relatively low in the population but there is a major longer term burden in morbidity and mortality to the individual.
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DOI：
10.1353/ppp.2007.0032
发表时间：
2006-12
期刊：
Philosophy, psychiatry, & psychology : PPP
影响因子：
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作者：
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发表时间：
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影响因子：
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