CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.
复制标题
记忆中的CD4下调CD4+ T细胞体内使非洲绿色猴子具有对进行性Sivagm感染的抗性。
作者：
非洲绿色猴（绿猴属）可以感染SIVagm，但不会发展成艾滋病。这种SIV的天然宿主，像白眉猴一样，保持着高水平的SIV复制，但已经进化到避免免疫缺陷。阐明自然宿主与SIV共存而无明显疾病的机制可能为理解AIDS发病机制提供重要信息。在这里，我们显示：（1）来自非洲绿色猴的许多CD 4 + T细胞在体内随着它们进入记忆池而下调CD 4，（2）记忆T细胞对CD 4的下调与SIV感染无关，（3）CD 4 −记忆T细胞维持通常归因于CD 4 T细胞的功能，包括产生IL-2，产生IL-17，FoxP 3的表达和CD 40 L的表达（4）CD 4表达的缺失保护这些T细胞免受体内SIVagm的感染，（5）这些CD 4 − T细胞可以维持MHC-II限制。这些数据表明，SIV诱导的疾病进展在自然宿主物种的情况下，可以部分地解释由保存的T细胞亚群，保持CD 4 T细胞功能，同时在体内抵抗SIV感染。
African green monkeys (genus Chlorocebus) can be infected with SIVagm, but do not develop AIDS. This natural host of SIV, like sooty mangabeys, maintains high levels of SIV replication but has evolved to avoid immunodeficiency. Elucidating the mechanisms that allow the natural hosts to co-exist with SIV without overt disease may provide crucial information to understand AIDS pathogenesis. Here we show: (1) many CD4+ T cells from African green monkeys down-regulate CD4 in vivo as they enter the memory pool, (2) down regulation of CD4 by memory T cells is independent of SIV infection, (3) the CD4− memory T cells maintain functions which are normally attributed to CD4 T cells including production of IL-2, production of IL-17, expression of FoxP3 and expression of CD40L (4) loss of CD4 expression protects these T cells from infection by SIVagm in vivo, and (5) these CD4− T cells can maintain MHC-II restriction. These data demonstrate that the absence of SIV-induced disease progression in natural hosts species may be partially explained by preservation of a subset of T cells that maintain CD4 T cell function while being resistant to SIV-infection in vivo.
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DOI：
10.1086/597476
发表时间：
2009-04-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Jiang W;Lederman MM;Hunt P;Sieg SF;Haley K;Rodriguez B;Landay A;Martin J;Sinclair E;Asher AI;Deeks SG;Douek DC;Brenchley JM
通讯作者：
Brenchley JM
影响因子：
6.4
作者：
Hunt, Peter W.;Brenchley, Jason;Deeks, Steven G.
通讯作者：
Deeks, Steven G.
影响因子：
29.4
作者：
Balagopal, Ashwin;Philp, Frances H.;Ray, Stuart C.
通讯作者：
Ray, Stuart C.
影响因子：
20.3
作者：
Dunham, Richard;Pagliardini, Paola;Silvestri, Guido
通讯作者：
Silvestri, Guido
影响因子：
3.7
作者：
Ancuta P;Kamat A;Kunstman KJ;Kim EY;Autissier P;Wurcel A;Zaman T;Stone D;Mefford M;Morgello S;Singer EJ;Wolinsky SM;Gabuzda D
通讯作者：
Gabuzda D