Lung cancer risk after exposure to polycyclic aromatic hydrocarbons: a review and meta-analysis.
Lung cancer risk after exposure to polycyclic aromatic hydrocarbons: a review and meta-analysis.
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DOI：
10.1289/ehp.6895
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发表时间：
2004-06
影响因子：
10.4
通讯作者：
Fletcher T
中科院分区：
文献类型：
--
作者：
Armstrong B;Hutchinson E;Unwin J;Fletcher T
典型的多环芳烃混合物是已确定的肺癌致癌物质，但定量暴露-反应关系不太清楚。为了阐明这种关系，我们对已发表的职业流行病学研究报告进行了综述和荟萃分析。纳入了39个队列。在100μg/立方米年苯并[a]芘的平均估计单位相对风险(URR)为1.2[95%可信区间(CI)，1.11-1.29]，对特定研究或分析方法不敏感。然而，URR因行业而异。焦炉、煤气厂和铝生产厂的估计平均值相似(1.15-1.17)。其他行业的平均URR较高，但估计不准确，沥青(17.5CI4.21-72.78)和烟囱清扫(16.2CI1.64-160.7)的URR显著高于以上三个行业。在行业内或与研究设计(包括是否根据吸烟进行调整)或暴露信息来源方面，URR没有统计上的显著差异。关于总粉尘暴露的有限信息并不表明粉尘暴露是一个重要的混杂因素，也没有改变这种影响。这些结果为风险评估提供了比以前更可靠的基础。
Typical polycyclic aromatic hydrocarbon mixtures are established lung carcinogens, but the quantitative exposure–response relationship is less clear. To clarify this relationship we conducted a review and meta-analysis of published reports of occupational epidemiologic studies. Thirty-nine cohorts were included. The average estimated unit relative risk (URR) at 100 μg/m3 years benzo[a]pyrene was 1.20 [95% confidence interval (CI), 1.11–1.29] and was not sensitive to particular studies or analytic methods. However, the URR varied by industry. The estimated means in coke ovens, gasworks, and aluminum production works were similar (1.15–1.17). Average URRs in other industries were higher but imprecisely estimated, with those for asphalt (17.5; CI, 4.21–72.78) and chimney sweeps (16.2; CI, 1.64–160.7) significantly higher than the three above. There was no statistically significant variation of URRs within industry or in relation to study design (including whether adjusted for smoking), or source of exposure information. Limited information on total dust exposure did not suggest that dust exposure was an important confounder or modified the effect. These results provide a more secure basis for risk assessment than was previously available.
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影响因子：
6.3
作者：
FORASTIERE, F;PUPP, N;PERUCCI, CA
通讯作者：
PERUCCI, CA
DOI：
10.1111/j.1749-6632.1976.tb23100.x
发表时间：
1976-01-01
影响因子：
5.2
作者：
HAMMOND, EC;SELIKOFF, IJ;SEIDMAN, H
通讯作者：
SEIDMAN, H
影响因子：
5
作者：
ARMSTRONG, B;TREMBLAY, C;THERIAULT, G
通讯作者：
THERIAULT, G
影响因子：
3.4
作者：
COLLINS, JF;BROWN, JP;MARTY, MA
通讯作者：
MARTY, MA
影响因子：
3.5
作者：
AXELSON, O;STEENLAND, K
通讯作者：
STEENLAND, K