Maternal brain reactive antibodies profile in autism spectrum disorder: an update.
Maternal brain reactive antibodies profile in autism spectrum disorder: an update.
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DOI：
10.1038/s41398-023-02335-3
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发表时间：
2023-02-03
影响因子：
6.8
通讯作者：
Brimberg, Lior
中科院分区：
文献类型：
--
作者：
Bagnall-Moreau, Ciara;Spielman, Benjamin;Brimberg, Lior
自闭症谱系障碍（ASD）是一种异质性神经发育障碍，具有涉及遗传和环境因素的多因素病因。在过去的二十年中，已经清楚的是，在子宫内暴露于毒素、炎症、微生物组和抗体（Ab）可能在ASD的病因学中起作用。母体脑反应性抗体存在于10-20%的ASD儿童母亲中，对发育中的大脑构成潜在风险，因为它们可以在妊娠期间进入大脑，在关键时期改变大脑发育。不同的母体抗脑抗体与ASD相关，并被认为与细胞外或细胞内神经元抗原结合。来自不同队列的临床数据支持与正常发育儿童的母亲相比，患有ASD的儿童的母亲中此类母体脑反应性Ab的患病率增加。非人灵长类动物和啮齿类动物的动物模型提供了令人信服的证据，支持这些抗体的致病作用。在这篇综述中，我们总结了来自临床和动物模型的数据，解决致病性母源性抗体在ASD中的作用。我们认为母体脑反应性抗体是一个被忽视的和有前途的研究领域，代表了一个可改变的风险因素，可能占ASD病例的20%。需要更多的研究来更好地描述导致ASD儿童风险的抗体，以了解我们是否可以预测ASD的此类病例，并更好地确定这些抗体的抗原特异性及其致病机制。
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with multifactorial etiologies involving both genetic and environmental factors. In the past two decades it has become clear that in utero exposure to toxins, inflammation, microbiome, and antibodies (Abs), may play a role in the etiology of ASD. Maternal brain-reactive Abs, present in 10–20% of mothers of a child with ASD, pose a potential risk to the developing brain because they can gain access to the brain during gestation, altering brain development during a critical period. Different maternal anti-brain Abs have been associated with ASD and have been suggested to bind extracellular or intracellular neuronal antigens. Clinical data from various cohorts support the increase in prevalence of such maternal brain-reactive Abs in mothers of a child with ASD compared to mothers of a typically developing child. Animal models of both non-human primates and rodents have provided compelling evidence supporting a pathogenic role of these Abs. In this review we summarize the data from clinical and animal models addressing the role of pathogenic maternal Abs in ASD. We propose that maternal brain-reactive Abs are an overlooked and promising field of research, representing a modifiable risk factor that may account for up to 20% of cases of ASD. More studies are needed to better characterize the Abs that contribute to the risk of having a child with ASD, to understand whether we can we predict such cases of ASD, and to better pinpoint the antigenic specificity of these Abs and their mechanisms of pathogenicity.
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影响因子：
11
作者：
Bruce MR;Jones KL;Vernon AC;Silverman JL;Crawley JN;Ellegood J;Lerch JP;Van de Water J
通讯作者：
Van de Water J
影响因子：
8.8
作者：
Block, Carina L.;Eroglu, Oznur;Mague, Stephen D.;Smith, Caroline J.;Ceasrine, Alexis M.;Sriworarat, Chaichontat;Blount, Cameron;Beben, Kathleen A.;Malacon, Karen E.;Ndubuizu, Nkemdilim;Talbot, Austin;Gallagher, Neil M.;Jo, Young Chan;Nyangacha, Timothy;Carlson, David E.;Dzirasa, Kafui;Eroglu, Cagla;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
DOI：
10.1097/dbp.0000000000001100
发表时间：
2022-10-01
影响因子：
2.4
作者：
Angkustsiri, Kathleen;Fussell, Jill J.;Bennett, Amanda;Schauer, Joseph;Ramirez-Celis, Alexandra;Hansen, Robin L.;Van de Water, Judy
通讯作者：
Van de Water, Judy
影响因子：
7.3
作者：
Burbelo PD;Iadarola MJ;Keller JM;Warner BM
通讯作者：
Warner BM
DOI：
10.1136/jnnp-2016-315251
发表时间：
2017-09
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Coutinho E;Jacobson L;Pedersen MG;Benros ME;Nørgaard-Pedersen B;Mortensen PB;Harrison PJ;Vincent A
通讯作者：
Vincent A