Maternal exposure to radiographic exams and major structural birth defects.
Maternal exposure to radiographic exams and major structural birth defects.
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DOI：
10.1002/bdra.23496
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Lim H;Beasley CW;Whitehead LW;Emery RJ;Agopian AJ;Langlois PH;Waller DK;National Birth Defects Prevention Study
美国进行的放射学检查越来越多，但很少有研究探讨母亲在围孕期接受放射学检查和出生缺陷的影响。通过一项基于人口的出生缺陷大型研究，评估母亲在围孕期接受放射检查与 19 类出生缺陷之间的关联。方法：我们研究了参加国家出生缺陷预防研究并在 1997 年至 2009 年期间分娩的 27,809 名病例母亲和 10,200 名对照母亲。根据母亲报告的放射检查类型、扫描的器官或身体部位以及检查发生的月份，确定母亲是否接受过向尿道、腰椎、腹部或骨盆提供电离辐射的放射检查。 0.9% 的母亲报告在围孕期接受过其中一种类型的放射线检查。我们观察到孕早期母亲暴露与孤立性 Dandy-Walker 畸形（比值比 = 7.7；95% 置信区间，1.8-33）和孤立性大动脉 d 转位（比值比 = 3.8；95% 置信区间，1.4-10.3）之间存在显着相关性。然而，孤立的 Dandy-Walker 畸形的结果仅基于两个暴露病例。 应谨慎解释这些结果，因为进行了多项统计测试，并且暴露测量是基于母亲报告。然而，我们的结果可能有助于为未来的研究提出假设。
An increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects. To assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population-based study of birth defects. Methods: We studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother’s report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred Overall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy-Walker malformation (odds ratio = 7.7; 95% confidence interval, 1.8–33) and isolated d-transposition of the great arteries (odds ratio = 3.8; 95% confidence interval, 1.4–10.3). However, the result for isolated Dandy-Walker malformation was based on only two exposed cases. These results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies.
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影响因子：
2.1
作者：
Choi, J. S.;Han, J. Y.;Nava-Ocampo, A. A.
通讯作者：
Nava-Ocampo, A. A.
影响因子：
2.6
作者：
Fernandez, JM;Vano, E;Guibelalde, E
通讯作者：
Guibelalde, E
DOI：
10.1093/biostatistics/1.1.113
发表时间：
2000-03-01
期刊：
Biostatistics (Oxford, England)
影响因子：
--
作者：
Greenland, S
通讯作者：
Greenland, S
DOI：
10.1056/nejmoa0901249
发表时间：
2009-08-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fazel R;Krumholz HM;Wang Y;Ross JS;Chen J;Ting HH;Shah ND;Nasir K;Einstein AJ;Nallamothu BK
通讯作者：
Nallamothu BK
影响因子：
19.7
作者：
Lazarus, Elizabeth;DeBenedectis, Carolynn;Mayo-Smith, William W.
通讯作者：
Mayo-Smith, William W.