Balancing ER-Mitochondrial Ca(2+) Fluxes in Health and Disease.
Balancing ER-Mitochondrial Ca(2+) Fluxes in Health and Disease.
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DOI：
10.1016/j.tcb.2021.02.003
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发表时间：
2021-07
影响因子：
19
通讯作者：
Bultynck G
中科院分区：
文献类型：
--
作者：
Loncke J;Kaasik A;Bezprozvanny I;Parys JB;Kerkhofs M;Bultynck G
Organelles cooperate with each other to control cellular homeostasis and cell functions by forming close connections through membrane contact sites. Important contacts are present between the endoplasmic reticulum (ER), the main intracellular Ca2+-storage organelle, and the mitochondria, the organelle not only responsible for the majority of cellular ATP production but also for switching on cell death processes. Several Ca2+-transport systems focalize at these contact sites, thereby enabling the efficient transmission of Ca2+ signals from the ER towards mitochondria. This provides a tight control of mitochondrial functions at the microdomain level. Here, we discuss how ER-mitochondrial Ca2+ transfers support cell function and how their dysregulation underlie, drive or contribute to pathogenesis and pathophysiology with major focus on cancer and neurodegeneration, but also with attention for other diseases such as diabetes and rare genetic diseases.
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影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
影响因子：
7.3
作者：
Cardenas, Cesar;Lovy, Alenka;Silva-Pavez, Eduardo;Urra, Felix;Mizzoni, Craig;Ahumada-Castro, Ulises;Bustos, Galdo;Jana, Fabian;Cruz, Pablo;Farias, Paula;Mendoza, Elizabeth;Huerta, Hernan;Murgas, Paola;Hunter, Martin;Rios, Melany;Cerda, Oscar;Georgakoudi, Irene;Zakarian, Armen;Molgo, Jordi;Foskett, J. Kevin
通讯作者：
Foskett, J. Kevin
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
影响因子：
11.4
作者：
Area-Gomez, Estela;Castillo, Maria Del Carmen Lara;Tambini, Marc D.;Guardia-Laguarta, Cristina;de Groof, Ad J. C.;Madra, Moneek;Ikenouchi, Junichi;Umeda, Masato;Bird, Thomas D.;Sturley, Stephen L.;Schon, Eric A.
通讯作者：
Schon, Eric A.
影响因子：
19
作者：
Csordás G;Weaver D;Hajnóczky G
通讯作者：
Hajnóczky G