IFNAR1 Degradation: A New Mechanism for Tumor Immune Evasion?
IFNAR1 Degradation: A New Mechanism for Tumor Immune Evasion?
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DOI:
10.1016/j.ccell.2017.01.012
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发表时间:
2017-02-13
期刊:
影响因子:
50.3
通讯作者:
Goldszmid RS
中科院分区:
文献类型:
--
作者:
Araya RE;Goldszmid RS
Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue, describe tumor-induced degradation of type I interferon receptor IFNAR1 chain as a new immune-evasion mechanism in colorectal cancers. Stabilizing IFNAR1 inhibits tumor growth and improves immunotherapy efficacy.
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DOI:
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