Host-directed editing of the SARS-CoV-2 genome.
Host-directed editing of the SARS-CoV-2 genome.
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DOI:
10.1016/j.bbrc.2020.10.092
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发表时间:
2021-01-29
影响因子:
3.1
通讯作者:
Pain A
中科院分区:
文献类型:
--
作者:
Mourier T;Sadykov M;Carr MJ;Gonzalez G;Hall WW;Pain A
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
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影响因子:
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发表时间:
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期刊:
Biochimica et biophysica acta. Molecular cell research
影响因子:
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Yount JS