Telomeres and Cancer: Resolving the Paradox.
Telomeres and Cancer: Resolving the Paradox.
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DOI：
10.1146/annurev-cancerbio-050420-023410
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发表时间：
2021-03
影响因子：
7.7
通讯作者：
Karlseder J
中科院分区：
文献类型：
--
作者：
Nassour J;Schmidt TT;Karlseder J
几十年来对细胞周期调控的研究为人类细胞寿命障碍及其在肿瘤发生过程中的失调提供了很好的见解。端粒是线性染色体的末端，在实现这些增殖边界和防止潜在癌细胞的繁殖方面发挥着重要作用。端粒的肿瘤抑制功能依赖于其启动DNA损伤信号通路和下游细胞事件的能力，从细胞周期扰动到炎症和细胞死亡。虽然端粒的肿瘤抑制作用是显而易见的，但最近的进展指出，端粒是早期和晚期癌症中发现的许多基因组畸变的主要来源，包括最近发现的突变现象chromothripsis。端粒缩短似乎是一把双刃剑，在致癌过程中可以向相反的方向发挥作用。本文综述了端粒在癌症中的双重作用，并提出了一个新的观点来调和端粒的悖论及其在癌症病因学中的意义。
Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes, perform an essential role in implementing these proliferative boundaries and preventing the propagation of potentially cancerous cells. The tumor-suppressive function of telomeres relies on their ability to initiate DNA damage signaling pathways and downstream cellular events, ranging from cell cycle perturbation to inflammation and cell death. While the tumor-suppressor role of telomeres is undoubtable, recent advances have pointed to telomeres as a major source of many of the genomic aberrations found in both early- and late-stage cancers, including the most recently discovered mutational phenomenon of chromothripsis. Telomere shortening appears as a double-edged sword that can function in opposing directions in carcinogenesis. This review focuses on the current knowledge of the dual role of telomeres in cancer and suggests a new perspective to reconcile the paradox of telomeres and their implications in cancer etiology.
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31种癌症类型的端粒长度和躯体改变的系统分析。
影响因子：
30.8
作者：
Barthel FP;Wei W;Tang M;Martinez-Ledesma E;Hu X;Amin SB;Akdemir KC;Seth S;Song X;Wang Q;Lichtenberg T;Hu J;Zhang J;Zheng S;Verhaak RG
通讯作者：
Verhaak RG
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
11.4
作者：
BRYAN, TM;ENGLEZOU, A;REDDEL, RR
通讯作者：
REDDEL, RR
影响因子：
30.8
作者：
Broccoli, D;Smogorzewska, A;deLange, T
通讯作者：
deLange, T
影响因子：
16.8
作者：
Amiard, Simon;Doudeau, Michel;Giraud-Panis, Marie-Josephe
通讯作者：
Giraud-Panis, Marie-Josephe