Delayed Gastric Emptying Is Not Associated with a Microbiological Diagnosis of Small Intestinal Bacterial Overgrowth.
Delayed Gastric Emptying Is Not Associated with a Microbiological Diagnosis of Small Intestinal Bacterial Overgrowth.
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DOI：
10.1007/s10620-020-06153-1
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发表时间：
2021-01
影响因子：
3.1
通讯作者：
Shin A
中科院分区：
文献类型：
--
作者：
Calderon G;Siwiec RM;Bohm ME;Nowak TV;Wo JM;Gupta A;Xu H;Shin A
小肠细菌过度生长（SIBO）患者的临床症状可能与胃轻瘫症状重叠。先前的研究表明小肠传输延迟与SIBO相关，但尚未显示胃排空延迟与SIBO之间的相关性。然而，这些研究通常依赖于呼吸测试的间接方法来诊断SIBO。本研究的目的是检查微生物学诊断的SIBO和延迟胃排空之间的关系，通过造影。在一项对既往研究参与者进行的单中心回顾性研究中，我们确定了73名通过小肠造影进行胃排空研究的参与者，这些参与者接受了小肠镜检查以诊断SIBO。根据空肠抽吸物培养结果对患者进行SIBO的微生物学诊断。采用胃轻瘫主要症状指数（GCSI）评分评估临床症状。我们比较了有和没有微生物学诊断的SIBO患者的胃排空延迟、2小时和4小时胃潴留以及胃轻瘫症状。在29名SIBO参与者和44名无SIBO参与者中，33名（45%）有胃排空延迟的证据。微生物学诊断SIBO和胃排空延迟之间无显著相关性。在有和没有SIBO的患者之间，2小时和4小时的保留百分比和总GCSI评分没有显著差异。虽然胃排空延迟在疑似SIBO患者中很常见，但胃排空与SIBO的微生物学诊断无关。
Clinical symptoms of patients with small intestinal bacterial overgrowth (SIBO) may overlap with symptoms of gastroparesis. Prior studies suggest delayed small intestinal transit is associated with SIBO, but have not shown an association between delayed gastric emptying and SIBO. However, these studies have generally relied on the indirect method of breath testing to diagnose SIBO. The aim of this study was to examine the association between a microbiological diagnosis of SIBO and delayed gastric emptying by scintigraphy. In a single-center retrospective study of previous research participants who presented for small bowel enteroscopy for diagnostic evaluation of SIBO, we identified 73 participants who underwent gastric emptying study by scintigraphy. A microbiological diagnosis of SIBO was made in patients based on culture results of jejunal aspirates. Clinical symptoms were assessed using the total gastroparesis cardinal symptom index (GCSI) score. We compared delayed gastric emptying, 2- and 4-hour gastric retention, and gastroparesis symptoms between patients with and without a microbiological diagnosis of SIBO. Among 29 participants with SIBO and 44 without SIBO, 33 (45%) had evidence of delayed gastric emptying. There was no significant association between a microbiological diagnosis of SIBO and delayed gastric emptying by scintigraphy. Percent retained at 2 and 4 hours and total GCSI scores did not differ significantly between those with and without SIBO. Although delayed gastric emptying is common in patients with suspected SIBO, gastric emptying is not associated with a microbiological diagnosis of SIBO.
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影响因子：
9.8
作者：
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通讯作者：
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