Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.
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癌症中蛋白质合成、能量代谢和自噬之间的串扰。

DOI:
10.1016/j.gde.2017.11.003
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发表时间:
2018-03
影响因子:
4
通讯作者:
Furic L
Furic L
中科院分区:
生物学2区
文献类型:
--
作者:
Lindqvist LM;Tandoc K;Topisirovic I;Furic L

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翻译是调控基因表达的关键步骤,也是细胞中能量消耗最大的过程之一。由上游信号通路的异常功能和/或翻译机制组成部分的表达或功能紊乱引起的翻译失调在癌症中很常见。在这篇综述中,我们讨论了一些新发现,这些发现突出了迄今为止未被重视的翻译装置信号传导方面,特别关注癌症中蛋白质合成、自噬和能量稳态之间的新联系。
Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.
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