Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films

Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films
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血小板、纤维蛋白原和内皮细胞与血浆沉积的 PEO 样膜的相互作用

DOI:
10.1016/j.apsusc.2011.11.013
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发表时间:
2012-02
影响因子:
6.7
通讯作者:
Huang, Nan
Huang, Nan
中科院分区:
材料科学1区
文献类型:
--
作者:
Yang, Zhilu;Wang, Jin;Li, Xin;Tu, Qiufen;Sun, Hong;Huang, Nan

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For blood-contacting biomedical implants like retrievable vena cava filters, surface-based diagnostic devices or in vivo sensors, limiting thrombosis and cell adhesion is paramount, due to a decrease even failure in performance. Plasma deposited PEO-like films were investigated as surface modifications. In this work, mixed gas composed of tetraethylene glycol dimethyl ether (tetraglyme) vapor and oxygen was used as precursor. It was revealed that plasma polymerization under high ratio of oxygen/tetraglyme led to deposition of the films that had high content of ether groups. This kind of PEO-like films had good stability in phosphate buffer solution. In vitro hemocompatibility and endothelial cell (EC) adhesion revealed low platelet adhesion, platelet activation, fibrinogen adhesion, EC adhesion and proliferation on such plasma deposited PEO-like films. This made it a potential candidate for the applications in anti-fouling surfaces of blood-contacting biomedical devices.
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