Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study.
Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study.
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DOI：
10.1155/2018/7279036
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发表时间：
2018
影响因子：
--
通讯作者：
Reed GL
中科院分区：
文献类型：
--
作者：
Zaidi SS;Ward RD;Ramanathan K;Yu X;Gladysheva IP;Reed GL
In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. This pilot study (n=48) compared plasma levels of corin, neprilysin, ANP, BNP, and cGMP in control patients with normal ejection fractions (mean EF 63 ± 3%) versus patients with systolic dysfunction, with (EF 24 ± 8%) and without (EF 27 ± 7%) decompensated HF (dHF), as defined by Framingham and BNP criteria. Mean ages, use of beta blockers, and ACE-inhibitors-angiotensin receptor blockers were similar between the groups. Corin levels were depressed in systolic dysfunction patients (797 ± 346 pg/ml) versus controls (1188 ± 549, p<0.02), but levels were not affected by dHF (p=0.77). In contrast, levels of neprilysin (p<0.01), cGMP (p<0.001), and ANP (p<0.001) were higher in systolic dysfunction patients than controls and were the highest in patients with dHF. Levels of neprilysin, ANP, BNP, and cGMP increased in patients with reduced systolic function and were the highest in dHF patients. Conversely, corin levels were low in patients with reduced EF with or without dHF. This pattern suggests possible enzymatic downregulation of natriuretic peptide activity in patients with reduced EF, which may have diagnostic and prognostic implications.
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影响因子：
13
作者：
Zhou, Xiang;Chen, Jian-Chang;Xu, Xiao-Hua
通讯作者：
Xu, Xiao-Hua
DOI：
10.1161/hypertensionaha.112.193631
发表时间：
2013-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Gladysheva IP;Wang D;McNamee RA;Houng AK;Mohamad AA;Fan TM;Reed GL
通讯作者：
Reed GL
DOI：
10.1161/hypertensionaha.115.06300
发表时间：
2016-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Tripathi R;Wang D;Sullivan R;Fan TH;Gladysheva IP;Reed GL
通讯作者：
Reed GL
DOI：
10.1161/circheartfailure.109.903849
发表时间：
2010-03
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Dong N;Chen S;Yang J;He L;Liu P;Zheng D;Li L;Zhou Y;Ruan C;Plow E;Wu Q
通讯作者：
Wu Q
DOI：
10.1152/ajpregu.00233.2012
发表时间：
2013-01-01
影响因子：
2.8
作者：
Ichiki, Tomoko;Boerrigter, Guido;Burnett, John C., Jr.
通讯作者：
Burnett, John C., Jr.