Myeloid-derived suppressor cells: paradoxical roles in infection and immunity.
Myeloid-derived suppressor cells: paradoxical roles in infection and immunity.
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DOI：
10.1159/000368233
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发表时间：
2015
影响因子：
5.3
通讯作者：
Yao ZQ
中科院分区：
文献类型：
--
作者：
Dai J;El Gazzar M;Li GY;Moorman JP;Yao ZQ
髓系来源的抑制细胞(MDSCs)是一组异质性的未成熟抑制细胞，是在病理条件下因异常的骨髓生成而产生的。尽管MDSCs以不同的绰号被识别已有20多年，但由于其免疫抑制特性，这些特殊的髓系细胞群最近获得了更多的关注，这些特性可以阻止宿主对不断增长的癌症或压倒性感染的免疫反应。虽然MDSCs可能通过限制过度的炎症过程来促进感染或组织损伤后的免疫稳态，但它们的扩张可能是以牺牲病原体清除为代价的，从而可能导致疾病持续。因此，MDSCs可能通过减弱例如抗肿瘤或抗感染的免疫反应而对宿主造成损害或顺从。本文综述了MDSCs的生物学和免疫学方面，包括MDSCs的产生、分布、运输及其激活、扩增、抑制功能和MDSCs与调节性T细胞之间的相互作用所涉及的因素，重点从感染和炎症的角度进行了综述。
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature suppressor cells that are generated due to aberrant myelopoiesis under pathological conditions. Although MDSCs have been recognized for more than 20 years under the guise of different monikers, these particular populations of myeloid cells gained more attention recently due to their immunosuppressive properties, which halt host immune responses to growing cancers or overwhelming infections. While MDSCs may contribute to immune homeostasis after infection or tissue injury by limiting excessive inflammatory processes, their expansion may be at the expense of pathogen elimination and thus may lead to disease persistence. Therefore, MDSCs may be either damaging or obliging to the host by attenuating, for example, anti-tumor or anti-infectious immune responses. In this review, we recapitulate the biological and immunological aspects of MDSCs, including their generation, distribution, trafficking and the factors involved in their activation, expansion, suppressive functions, and interplay between MDSCs and regulatory T cells, with a focus on the perspectives of infection and inflammation.
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DOI：
10.1186/cc5055
发表时间：
2006
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cavaillon JM;Adib-Conquy M
通讯作者：
Adib-Conquy M
影响因子：
5.4
作者：
Arocena, Alfredo R.;Onofrio, Luisina I.;Gea, Susana
通讯作者：
Gea, Susana
影响因子：
6.4
作者：
Garg, Ankita;Spector, Stephen A.
通讯作者：
Spector, Stephen A.
影响因子：
8.7
作者：
Goh C;Narayanan S;Hahn YS
通讯作者：
Hahn YS
影响因子：
4.4
作者：
Dilek, Nahzli;Poirier, Nicolas;Vanhove, Bernard
通讯作者：
Vanhove, Bernard