Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics.
Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics.
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使用蛋白质组学，磷酸蛋白质组学和代谢组学对背部根神经节的综合多素分析。
DOI：
10.1038/s41598-022-21394-y
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发表时间：
2022-10-11
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain soma of sensory neurons and modulate sensory signal transduction into the central nervous system. In this study, we aimed to gain a deeper understanding of changes in molecular pathways in the DRG of DPN patients with chronic pain. We recently reported transcriptomic changes in the DRG with DPN. Here, we expand upon those results with integrated metabolomic, proteomic, and phospho-proteomic analyses to compare the molecular profiles of DRG from DPN donors and DRG from control donors without diabetes or chronic pain. Our analyses identified decreases of select amino acids and phospholipid metabolites in the DRG from DPN donors, which are important for cellular maintenance. Additionally, our analyses revealed changes suggestive of extracellular matrix (ECM) remodeling and altered mRNA processing. These results reveal new insights into changes in the molecular profiles associated with DPN.
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DOI：
10.1530/joe-12-0356
发表时间：
2013-01
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Hinder LM;Vivekanandan-Giri A;McLean LL;Pennathur S;Feldman EL
通讯作者：
Feldman EL
DOI：
10.1016/j.jpain.2014.09.010
发表时间：
2014-12
期刊：
The journal of pain
影响因子：
--
作者：
Goswami SC;Mishra SK;Maric D;Kaszas K;Gonnella GL;Clokie SJ;Kominsky HD;Gross JR;Keller JM;Mannes AJ;Hoon MA;Iadarola MJ
通讯作者：
Iadarola MJ
影响因子：
16.2
作者：
Gregg, EW;Sorlie, P;Geiss, L
通讯作者：
Geiss, L
DOI：
10.1152/ajpheart.00954.2013
发表时间：
2014-04-01
影响因子：
4.8
作者：
Dalal, Suman;Zha, Qinqin;Singh, Krishna
通讯作者：
Singh, Krishna
影响因子：
8.1
作者：
Leal-Julià M;Vilches JJ;Onieva A;Verdés S;Sánchez Á;Chillón M;Navarro X;Bosch A
通讯作者：
Bosch A