Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect.
Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect.
复制标题
使用 H215O 和动态正电子发射断层扫描测量绝对心肌血流量。
作者：
Hidehiro Jida;I. Kanno;A. Takahashi;S. Miura;M. Murakami;Kazuhiro Takahashi;Y. Ono;F. Shishido;A. Inugami;N. Tomura;S. Higano;H. Fujita;H. Sasaki;H. Nakamichi;Shigenori;Mizusawa;Y. Kondo;K. Uemura
本文介绍了一种用H215 O和动态正电子发射断层扫描测量心肌绝对血流量的在体技术。该技术基于一种新的模型，该模型涉及组织分数的概念，其被定义为组织块在感兴趣区域的体积中的分数。通过正电子发射断层扫描对心肌进行动态成像，从静脉推注H215 O开始。用β射线探测器连续测量动脉输入功能。还获得了吸入C15 O后的单独图像，用于校正血液中的H215 O放射性。用动态技术在感兴趣区分析下计算了15例受试者的绝对心肌血流量和组织分数。这些结果似乎与冠状动脉造影结果一致。正常人绝对心肌血流量的平均值为0.95 ± 0.09 ml/min/g。该技术检测到三支血管疾病患者心肌血流量的弥漫性减少。
An in vivo technique was developed for measuring the absolute myocardial blood flow with H215O and dynamic positron-emission tomography. This technique was based on a new model involving the concept of the tissue fraction, which was defined as the fraction of the tissue mass in the volume of the region of interest. The myocardium was imaged dynamically by positron-emission tomography, starting at the time of intravenous bolus injection of H215O. The arterial input function was measured continuously with a beta-ray detector. A separate image after C15O inhalation was also obtained for correction of the H215O radioactivity in the blood. The absolute myocardial blood flow and the tissue fraction were calculated for 15 subjects with a kinetic technique under region-of-interest analysis. These results seem consistent with their coronary angiographic findings. The mean value of the measured absolute myocardial blood flows in normal subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse decrease of myocardial blood flow in patients with triple-vessel disease.
用氧 15 水和正电子计算机断层扫描定量测量心肌血流量：潜力和问题的评估。
DOI：
--
发表时间：
1985
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Huang,SC;Schwaiger,M;Carson,RE;Carson,J;Hansen,H;Selin,C;Hoffman,EJ;MacDonald,N;Schelbert,HR;Phelps,ME
通讯作者：
Phelps,ME
DOI：
--
发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
用 H(2)15O 和正电子发射断层扫描表征亚临界冠状动脉狭窄的功能意义。
影响因子：
37.8
作者：
Knabb,RM;Fox,KA;Sobel,BE;Bergmann,SR
通讯作者：
Bergmann,SR