Nitric oxide inhibits uterine contractility during pregnancy but not during delivery.
Nitric oxide inhibits uterine contractility during pregnancy but not during delivery.
复制标题
一氧化氮会抑制怀孕期间的子宫收缩力，但不会抑制分娩期间的子宫收缩力。
作者：
C. Yallampalli;R. Garfield;M. Byam
一氧化氮介导各种生物学现象，包括血管平滑肌松弛。在本研究中，我们试图确定是否L-精氨酸一氧化氮松弛系统存在于子宫，如果它调节收缩在怀孕期间。底物和一氧化氮和一氧化氮气体的供体引起大量的松弛的自发收缩的组织从大鼠子宫在体外妊娠期间。一氧化氮合酶和可溶性鸟苷酸环化酶抑制剂逆转L-精氨酸的舒张作用。在器官培养中，一氧化氮由子宫产生。L-精氨酸对孕鼠子宫的舒张作用在自然分娩期和产后均减弱。一氧化氮的产生也大大减少在劳动。这些结果表明，L-精氨酸-一氧化氮-松弛系统存在于子宫中，它在妊娠期间抑制收缩，但在分娩期间不抑制收缩。
Nitric Oxide mediates various biological phenomena, including vascular smooth muscle relaxation. In the present study, we sought to determine if an L-arginine nitric oxide-relaxation system is present in the uterus and if it modulates contractility during pregnancy. The substrate and a donor of nitric oxide and nitric oxide gas caused substantial relaxation of the spontaneous contractility of tissues from the rat uterus in vitro during pregnancy. Inhibitors of nitric oxide synthase and soluble guanylate cyclase reversed the relaxation effects of L-arginine. Nitric oxide was produced by the uterus in organ culture. Relaxation effects of L-arginine on the pregnant rat uterus were diminished at the time of spontaneous labor and postpartum. Nitric oxide production was also substantially reduced during labor. These results show that an L-arginine-nitric oxide-relaxation system is present in the uterus and it inhibits contractility during pregnancy but not during labor.
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影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
DOI：
--
发表时间：
1981-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
L. Ignarro;H. Lippton;J. Edwards;W. Baricos;A. Hyman;P. Kadowitz;C. A. Gruetter
通讯作者：
L. Ignarro;H. Lippton;J. Edwards;W. Baricos;A. Hyman;P. Kadowitz;C. A. Gruetter
一氧化氮的自发释放抑制犬胃平滑肌的电瞬变、Ca2+ 瞬变和机械瞬变。
DOI：
10.1113/jphysiol.1992.sp018921
发表时间：
1992
期刊：
The Journal of physiology
影响因子：
--
作者：
Ozaki,H;Blondfield,DP;Hori,M;Publicover,NG;Kato,I;Sanders,KM
通讯作者：
Sanders,KM
血管平滑肌中硝普钠代谢激活一氧化氮。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Kowaluk,EA;Seth,P;Fung,HL
通讯作者：
Fung,HL