Multiomics integration-based molecular characterizations of COVID-19.
Multiomics integration-based molecular characterizations of COVID-19.
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DOI：
10.1093/bib/bbab485
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发表时间：
2022-01-17
影响因子：
9.5
通讯作者：
Wheelock ÅM
中科院分区：
文献类型：
--
作者：
Li CX;Gao J;Zhang Z;Chen L;Li X;Zhou M;Wheelock ÅM
由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的2019年冠状病毒病(新冠肺炎)大流行迅速成为全球卫生挑战，导致前所未有的社会和经济后果。SARS-CoV-2的致病机制既独特又复杂。组学规模的研究正在迅速兴起，并为解开SARS-CoV-2病理生物学之谜提供了巨大的潜力，以及在诊断、潜在的药物靶点、风险分层、治疗反应、疫苗开发和治疗创新方面取得进展。本文综述了基于多组学整合的新冠肺炎分子特征研究的各个方面，包括转录组学、蛋白质组学、基因组学、脂类组学、免疫组学和代谢组学的整合，以探索病毒靶点，并利用系统生物学工具开发合适的治疗方案。此外，这篇综述还包括与疾病发病机制和毒力、宿主遗传变异的作用以及有助于理解新冠肺炎性状的一系列免疫和炎症表型相关的组学研究的摘要。对这篇综述的见解结合了现有的战略和多组学整合概况，可能有助于进一步推进我们对新冠肺炎的了解。
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences. The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.
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影响因子：
8.5
作者：
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