Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models.
Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models.
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DOI：
10.1016/j.compbiomed.2022.106058
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发表时间：
2022-10
影响因子：
7.7
通讯作者：
中科院分区：
文献类型：
--
作者：
儿童的上呼吸道在6岁左右经历发育变化，导致成人和儿童的解剖结构不同。这些差异包括环状环区的形状、最狭窄的狭窄位置和会厌的角度，所有这些都有望改变局部流体动力学特征和随后的上呼吸道沉积和下游吸入治疗药物的气雾剂输送。在这项工作中，我们量化了两个由CT扫描得出的健康受试者6岁上呼吸道的“儿童”样和“成人”样的几何和流体动力学特征，并与理想化的模型进行了比较。这两个CT扫描模型混合了“成人”和“儿科”的解剖特征，其中受试者B比受试者A表现出更多的“儿科”特征，而理想化的模型则完全表现出“成人”的特征。通过计算流体-粒子动力学，这些解剖特征的差异产生了不同的局部流体轮廓，不同模型之间的气溶胶沉积发生了变化。值得注意的是，理想化的模型更好地预测了受试者A的沉积特征，更接近于成人的模型，包括撞击参数与一定流速和颗粒直径范围内的沉积分数之间的关系，以及近似的药物颗粒尺寸分布模型的沉积。即使是这个有限的数据集，我们的结果也表明，在开发儿科吸入疗法时，有一些关键的个性化指标受到解剖学发展的影响，应该被考虑在内。量化解剖发育和与气溶胶沉积相关的有可能高通量地描述发育特征，并为儿科应用提供所需的气溶胶特性。
The upper airways of children undergo developmental changes around age 6, yielding differences between adult and pediatric anatomies. These differences include the cricoid ring area shape, the location of narrowest constriction, and the angle of the epiglottis, all of which are expected to alter local fluid dynamic profiles and subsequent upper airway deposition and downstream aerosol delivery of inhaled therapeutics. In this work, we quantify “pediatric”-like and “adult”-like geometric and fluid-dynamic features of two computerized tomography (CT)-scan derived models of 6-year-old upper airways in healthy subjects and compare to an idealized model. The two CT-scan models had a mixture of “adult”- and “pediatric”-like anatomical features, with Subject B exhibiting more “pediatric”-like features than Subject A, while the idealized model exhibited entirely “adult”-like features. By computational fluid-particle dynamics, these differences in anatomical features yielded distinct local fluid profiles with altered aerosol deposition between models. Notably, the idealized model better predicted deposition characteristics of Subject A, the more “adult”-like model, including the relationship between the impaction parameter, and the fraction of deposition across a range of flow rates and particle diameters, as well as deposition of an approximate pharmaceutical particle size distribution model. Our results with even this limited dataset suggest that there are key personalized metrics that are influenced by anatomical development which should be considered when developing pediatric inhalable therapeutics. Quantifying anatomical development and correlating to aerosol deposition has the potential for high-throughput developmental characterization and informing desired aerosol characteristics for pediatric applications.
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影响因子：
6.6
作者：
Ehrmann S;Schmid O;Darquenne C;Rothen-Rutishauser B;Sznitman J;Yang L;Barosova H;Vecellio L;Mitchell J;Heuze-Vourc'h N
通讯作者：
Heuze-Vourc'h N
婴儿、儿童和成人气管支气管内的颗粒沉积
影响因子：
9.8
作者：
Deng, Qihong;Ou, Cuiyun;Xiang, Yuguang
通讯作者：
Xiang, Yuguang
影响因子：
4.5
作者：
Feng, Yu;Zhao, Jianan;Yi, Hang
通讯作者：
Yi, Hang
影响因子：
8.8
作者：
ECKENHOFF, JE
通讯作者：
ECKENHOFF, JE
影响因子：
4.6
作者：
Bentsen, Mariann H L;Eriksen, Morten;Halvorsen, Thomas
通讯作者：
Halvorsen, Thomas