Parcellation of the murine cortical hindlimb area is demonstrated by its subcortical connectivity and cytoarchitecture
Parcellation of the murine cortical hindlimb area is demonstrated by its subcortical connectivity and cytoarchitecture
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小鼠皮质后肢区域的分割通过其皮质下连接性和细胞结构来证明
DOI：
10.1002/cne.25313
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发表时间：
2022
影响因子：
2.5
通讯作者：
Sakurai Masaki
中科院分区：
文献类型：
--
作者：
Kameda Hiroshi;Murabe Naoyuki;Mizukami Hiroaki;Ozawa Keiya;Hayashi Toshihiro;Sakurai Masaki
尽管已知皮质脊髓神经元分布在初级运动皮层和体感皮层 (S1) 中，但其纤维到腰脊髓灰质的投射模式的细节在很大程度上仍然未知，尤其是在啮齿类动物中。我们之前研究了小鼠第四腰脊髓段 (L4) (L4 Cx) 的皮质区域投射到灰质的情况。在本研究中，我们将顺行示踪剂注入多个部位以覆盖整个 L4 Cx。我们发现（1）L4 Cx 的喙内侧部分投射到腰脊髓灰质的中间区和腹侧区，（2）外侧部分投射到内侧背角，（3）尾部部分投射到外侧背角。我们还发现，喙内侧部分和尾外侧部分之间的边界对应于无颗粒皮层和颗粒皮层之间的边界。对支配后肢及其相关区域皮肤的皮质投射细胞和初级感觉神经元形成的体位模式的分析表明，外侧部分对应于S1后肢区域，尾部对应于S1躯干区域。对 L4 Cx 丘脑神经支配的检查显示，尾外侧 L4 Cx 集中投射到腹基底复合体 (VB) 和后复合体 (PO)，而内侧 L4 Cx 广泛投射到 PO，但很少投射到 VB。这些发现表明 L4 Cx 被划分为由细胞结构和皮层下投影定义的子区域。
Although corticospinal neurons are known to be distributed in both the primary motor and somatosensory cortices (S1), details of the projection pattern of their fibers to the lumbar cord gray matter remain largely uncharacterized, especially in rodents. We previously investigated the cortical area projecting to the gray matter of the fourth lumbar cord segment (L4) (L4 Cx) in mice. In the present study, we injected an anterograde tracer into multiple sites to cover the entire L4 Cx. We found that (1) the rostromedial part of the L4 Cx projects to the intermediate and ventral zones of the lumbar cord gray matter, (2) the lateral part projects to the medial dorsal horn, and (3) the caudal part projects to the lateral dorsal horn. We also found that the border between the rostromedial and caudolateral parts corresponds to the border between the agranular and granular cortex. Analysis of the somatotopic patterns formed by the cortical projection cells and the primary sensory neurons innervating the skin of the hindlimb and its related area suggests that the lateral part corresponds to the S1 hindlimb area and the caudal part to the S1 trunk area. Examination of thalamic innervation by the L4 Cx revealed that the caudolateral L4 Cx focally projects to the ventrobasal complex (VB) and the posterior complex (PO), while the medial L4 Cx widely projects to the PO but little to the VB. These findings suggest that the L4 Cx is parceled into subregions defined by the cytoarchitecture and subcortical projection.
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影响因子：
8.8
作者：
Ueno M;Nakamura Y;Li J;Gu Z;Niehaus J;Maezawa M;Crone SA;Goulding M;Baccei ML;Yoshida Y
通讯作者：
Yoshida Y
大鼠皮质脊髓神经元的体细胞分布
影响因子：
2.5
作者：
J. Ullán;J. Artieda
通讯作者：
J. Artieda
影响因子：
0.9
作者：
LI, XG;FLORENCE, SL;KAAS, JH
通讯作者：
KAAS, JH
影响因子：
3.7
作者：
Tennant, Kelly A.;Adkins, DeAnna L.;Jones, Theresa A.
通讯作者：
Jones, Theresa A.
猫从脑干和感觉运动皮层到脊柱增大的下降投射
影响因子：
2
作者：
N. L. Hayes;A. Rustioni
通讯作者：
A. Rustioni