Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.
Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.
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DOI：
10.1002/wnan.1242
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发表时间：
2014-01
影响因子：
8.6
通讯作者：
Paulmurugan, Ramasamy
中科院分区：
文献类型：
--
作者：
Devulapally, Rammohan;Paulmurugan, Ramasamy
纳米技术的进步为癌症诊断和治疗的发展提供了强大而有效的工具。目前有许多纳米载体被批准用于癌症治疗。近年来，可生物降解聚合物纳米颗粒(NPs)作为一种靶向递送多种药物、基因、蛋白质、多肽、疫苗和其他生物分子的载体受到了人们的广泛关注，而且没有太大的毒性。本文将重点介绍近年来聚合物为基础的纳米载体在各种药物和小分子沉默RNA的负载和输送治疗不同类型癌症方面的最新进展。
Advances in nanotechnology have provided powerful and efficient tools in development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles (NPs) have attracted a considerable attention for their ability to function as a possible carrier for target-specific delivery of various drugs, genes, proteins, peptides, vaccines, and other biomolecules in humans without much toxicity. This review will specifically focus on the recent advances in polymer-based nanocarriers for various drugs and small silencing RNA’s loading and delivery to treat different types of cancer.
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