Relationship between Overall Survival of Patients with Non-Small Cell Lung Cancer and Whole-Body Metabolic Tumor Burden Seen on Postsurgical Fluorodeoxyglucose PET Images.
Relationship between Overall Survival of Patients with Non-Small Cell Lung Cancer and Whole-Body Metabolic Tumor Burden Seen on Postsurgical Fluorodeoxyglucose PET Images.
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DOI：
10.1148/radiol.14141398
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发表时间：
2015-06
期刊：
影响因子：
19.7
通讯作者：
Pu Y
中科院分区：
文献类型：
--
作者：
Zhang C;Liao C;Penney BC;Appelbaum DE;Simon CA;Pu Y
检验非小细胞肺癌（NSCLC）患者术后氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）图像上的全身代谢肿瘤负荷（MTBWB）与其总生存期（OS）相关的假设。机构审查委员会批准了本研究，并免除了获得知情同意书的要求。回顾性分析了142例接受术后FDG PET/CT的NSCLC患者（69例男性，73例女性;中位年龄67.7岁）。测量全身代谢肿瘤体积（MTVWB）、全身总病变糖酵解（TLGWB）和全身最大标准化摄取值（SUVWBmax）。OS作为研究的主要终点。Kaplan-Meier曲线和考克斯回归用于评估PET/CT标记物与OS之间的相关性。观察者间变异性较低，如SUVWB max、MTVWB和TLGWB的组内相关系数高于0.94所示。当与术后FDG PET/CT结果阴性的患者相比时，基于对数秩检验（P = 0.001）和单变量考克斯模型（风险比= 2.805，P = 0.001），发现存在FDG-亲肿瘤的患者的OS显著降低。在FDG-avid肿瘤患者中，在校正患者年龄、性别、TNM再分期和术后PET/CT研究后的治疗后，在单变量或多变量分析中，OS与ln MTVWB（P <.001）、ln TLGWB（P <.001）和ln SUVWBmax（P < .010）之间存在显著相关性。根据MTVWB（11.54 mL，P = .004）、TLGWB（32.38 mL，P < .001）或SUVWBmax（4.93，P = .023）的中位数进行二分的组间OS差异具有显著性。术后FDG PET/CT的MTBWB和肿瘤最大标准化摄取与NSCLC患者的OS相关，与年龄、性别、TNM分期和术后PET/CT研究后的治疗无关。
To test the hypothesis that whole-body metabolic tumor burden (MTBWB) on postsurgical fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) images in patients with non–small cell lung cancer (NSCLC) is associated with their overall survival (OS). The institutional review board approved this study and waived the requirement for obtaining informed consent. One hundred forty-two patients with NSCLC (69 men, 73 women; median age, 67.7 years) who underwent postsurgical FDG PET/CT were retrospectively reviewed. The whole-body metabolic tumor volume (MTVWB), whole-body total lesion glycolysis (TLGWB), and whole-body maximum standardized uptake value (SUVWBmax) were measured. OS served as the primary end point of the study. Kaplan-Meier curves and Cox regression were used to assess the association between PET/CT markers and OS. The interobserver variability was low, as demonstrated with intraclass correlation coefficients higher than 0.94 for SUVWBmax, MTVWB, and TLGWB. When compared with those with negative postsurgical FDG PET/CT findings, a significant decrease of OS was found in patients with the presence of FDG-avid tumor on the basis of both a log-rank test (P = .001) and a univariate Cox model (hazard ratio = 2.805, P = .001). In patients with FDG-avid tumor, there was a significant association between OS and ln MTVWB (P < .001), ln TLGWB (P < .001), and ln SUVWBmax (P < .010) in either univariate or multivariate analysis, after adjusting for patient age, sex, TNM restage, and therapy after postsurgical PET/CT studies. The OS differences between the groups dichotomized by the median value of MTVWB (11.54 mL, P = .004), TLGWB (32.38 mL, P < .001), or SUVWBmax (4.93, P = .023) were significant. MTBWB and tumor maximum standardized uptake at postsurgical FDG PET/CT are related to the patient's OS in NSCLC, independent of age, sex, TNM restaging, and therapy after postsurgical PET/CT studies.
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影响因子：
5
作者：
Patz, EF;Connolly, J;Herndon, J
通讯作者：
Herndon, J
DOI：
10.1007/s00259-011-1934-6
发表时间：
2012-01-01
影响因子：
9.1
作者：
Liao, Shengri;Penney, Bill C.;Pu, Yonglin
通讯作者：
Pu, Yonglin
影响因子：
4.8
作者：
Zhang, Hao;Wroblewski, Kristen;Pu, Yonglin
通讯作者：
Pu, Yonglin
影响因子：
9
作者：
Hyun, Seung Hyup;Choi, Joon Young;Kim, Byung-Tae
通讯作者：
Kim, Byung-Tae
影响因子：
19.7
作者：
Chen, Helen H. W.;Chiu, Nan-Tsing;Lee, Bi-Fang
通讯作者：
Lee, Bi-Fang