Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.
Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.
复制标题
DOI：
10.1016/j.nano.2012.10.010
复制
发表时间：
2013-05
影响因子：
5.4
通讯作者：
Baker, Cheryl H.
中科院分区：
文献类型：
--
作者：
Wason, Melissa S.;Colon, Jimmie;Das, Soumen;Seal, Sudipta;Turkson, James;Zhao, Jihe;Baker, Cheryl H.
放射治疗（RT）的副作用仍然是胰腺癌治疗中最具挑战性的问题。在本报告中，我们确定了氧化铈纳米颗粒（CONP）是否以及如何使胰腺癌细胞对rt敏感。CONP预处理在酸性无细胞溶液和酸性人胰腺癌细胞中优先增强辐射诱导的活性氧（ROS）的产生。在酸性环境中，CONPs倾向于清除超氧自由基而不是羟基过氧化氢，导致后者的积累，而在中性pH下，CONPs清除两者。在RT之前，CONP治疗显著增强了培养细胞和肿瘤细胞的凋亡，抑制了胰腺肿瘤的生长，而不损害正常组织或宿主小鼠。综上所述，这些结果确定CONPs是一种潜在的新型rt -敏化剂和改善胰腺癌治疗的保护剂。
Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhanced radiation-induced reactive oxygen species (ROS) production preferentially in acidic cell-free solutions as well as acidic human pancreatic cancer cells. In acidic environments, CONPs favor the scavenging of superoxide radical over the hydroxyl peroxide resulting in accumulation of the latter whereas in neutral pH CONPs scavenge both. CONP treatment prior to RT markedly potentiated the cancer cell apoptosis both in culture and in tumors and the inhibition of the pancreatic tumor growth without harming the normal tissues or host mice. Taken together, these results identify CONPs as a potentially novel RT-sensitizer as well as protectant for improving pancreatic cancer treatment.
登录
查看更多内容
叶酸共轭二氧化硅修饰的金纳米棒用于 X 射线/CT 成像引导的双模辐射和光热治疗
影响因子：
14
作者：
Huang, Peng;Bao, Le;Cui, Daxiang
通讯作者：
Cui, Daxiang
影响因子：
3.7
作者：
Karakoti, A. S.;Kuchibhatla, Satyanarayana V. N. T.;Seal, S.
通讯作者：
Seal, S.
影响因子：
3.6
作者：
Krug, Lee M.;Curley, Tracy;Kelly, W. Kevin
通讯作者：
Kelly, W. Kevin
影响因子：
14
作者：
Heckert, Eric G.;Karakoti, Ajay S.;Self, William T.
通讯作者：
Self, William T.
影响因子：
--
作者：
Oleshko, VR;Howe, JM;Seal, S
通讯作者：
Seal, S