The solution structure of the bovine leukaemia virus matrix protein and similarity with lentiviral matrix proteins.
The solution structure of the bovine leukaemia virus matrix protein and similarity with lentiviral matrix proteins.
复制标题
牛白血病病毒基质蛋白的溶液结构及其与慢病毒基质蛋白的相似性。
作者：
Steven J. Matthews;Michael Mikhailov;Arsène Burny;Polly Roy
在成熟的病毒粒子中，发现逆转录病毒基质蛋白与病毒膜的内面相关。它们在确定病毒组装的形态发生中起着关键作用。我们用异核核磁共振确定了牛白血病病毒(BLV)基质蛋白的三维溶液结构。该蛋白质包含四个由短的、部分结构化的环连接的主要螺旋。尽管与慢病毒没有序列相似之处，但其结构与人类和猿类免疫缺陷病毒的同等蛋白质显示出耐人寻味的同源性。在36个等效螺旋位置的主干原子上观测到的均方根偏差为3.78埃。这种相似性意味着C型逆转录病毒基质蛋白可能有一个共同的组装单位。
In the mature virion, retroviral matrix proteins are found in association with the inner face of the viral membrane. They play a critical role in determining the morphogenesis of virus assembly. We have determined the three‐dimensional solution structure of the bovine leukaemia virus (BLV) matrix protein by heteronuclear nuclear magnetic resonance. The protein contains four principal helices that are joined by short, partially structured loops. Despite no sequence similarity with the lentiviruses, the structure shows an intriguing homology with the equivalent protein from the human and simian immunodeficiency viruses. A root‐mean‐square deviation of 3.78 angstrom is observed over the backbone atoms of 36 equivalent helical positions. The similarity implies a possible common assembly unit for the matrix proteins of type C retroviruses.
DOI：
10.1073/pnas.90.13.6125
发表时间：
1993-07-01
影响因子：
11.1
作者：
BUKRINSKY, MI;SHAROVA, N;STEVENSON, M
通讯作者：
STEVENSON, M
人类免疫缺陷病毒结构：抗病毒设计的影响。
影响因子：
--
作者：
Arnold,E;Arnold,GF
通讯作者：
Arnold,GF