The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke.
The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke.
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DOI：
10.1186/s12974-021-02090-6
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发表时间：
2021-02-20
影响因子：
9.3
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Gong P;Liu Y;Gong Y;Chen G;Zhang X;Wang S;Zhou F;Duan R;Chen W;Huang T;Wang M;Deng Q;Shi H;Zhou J;Jiang T;Zhang Y
探讨中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）和淋巴细胞与单核细胞比率（LMR）与急性缺血性脑卒中（AIS）患者溶栓后早期神经系统结局（包括早期神经系统改善（ENI）和早期神经系统恶化（END））的关系。纳入2016年4月至2019年9月接受静脉溶栓的AIS患者。溶栓前采集血细胞计数样本。溶栓后END定义为溶栓后24小时内美国国立卫生研究院卒中量表(NIHSS)评分增加≥4。溶栓后ENI定义为NIHSS评分下降≥4或24小时内完全恢复。采用多项 Logistic 回归分析探讨 NLR、PLR 和 LMR 与溶栓后 END 和 ENI 的关系。我们还使用受试者工作特征曲线分析来评估三个比率预测 END 和 ENI 的辨别能力。在1060名招募的患者中，共有193名（18.2%）被诊断为END，398名（37.5%）被诊断为ENI。多项 Logistic 模型表明，NLR（比值比 [OR]，1.385；95% 置信区间 [CI] 1.238–1.551，P = 0.001）、PLR（OR，1.013；95% CI 1.009–1.016，P = 0.001）和 LMR（OR，0.680；95% CI） 0.560–0.825，P = 0.001）是溶栓后END的独立因素。此外，NLR（OR，0.713；95% CI 0.643-0.791，P = 0.001）是溶栓后 ENI 的独立因素。区分 END 的 NLR、PLR 和 LMR 曲线下面积 (AUC) 分别为 0.763、0.703 和 0.551。区分 ENI 的 NLR、PLR 和 LMR 的 AUC 分别为 0.695、0.530 和 0.547。 NLR、PLR 和 LMR 与溶栓后 END 相关。 NLR 和 PLR 可以预测溶栓后 END。 NLR与溶栓后ENI相关。在线版本包含可在 10.1186/s12974-021-02090-6 获取的补充材料。
To investigate the association of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post-thrombolysis early neurological outcomes including early neurological improvement (ENI) and early neurological deterioration (END) in patients with acute ischemic stroke (AIS). AIS patients undergoing intravenous thrombolysis were enrolled from April 2016 to September 2019. Blood cell counts were sampled before thrombolysis. Post-thrombolysis END was defined as the National Institutes of Health Stroke Scale (NIHSS) score increase of ≥ 4 within 24 h after thrombolysis. Post-thrombolysis ENI was defined as NIHSS score decrease of ≥ 4 or complete recovery within 24 h. Multinomial logistic regression analysis was performed to explore the relationship of NLR, PLR, and LMR to post-thrombolysis END and ENI. We also used receiver operating characteristic curve analysis to assess the discriminative ability of three ratios in predicting END and ENI. Among 1060 recruited patients, a total of 193 (18.2%) were diagnosed with END and 398 (37.5%) were diagnosed with ENI. Multinomial logistic model indicated that NLR (odds ratio [OR], 1.385; 95% confidence interval [CI] 1.238–1.551, P = 0.001), PLR (OR, 1.013; 95% CI 1.009–1.016, P = 0.001), and LMR (OR, 0.680; 95% CI 0.560–0.825, P = 0.001) were independent factors for post-thrombolysis END. Moreover, NLR (OR, 0.713; 95% CI 0.643–0.791, P = 0.001) served as an independent factor for post-thrombolysis ENI. Area under curve (AUC) of NLR, PLR, and LMR to discriminate END were 0.763, 0.703, and 0.551, respectively. AUC of NLR, PLR, and LMR to discriminate ENI were 0.695, 0.530, and 0.547, respectively. NLR, PLR, and LMR were associated with post-thrombolysis END. NLR and PLR may predict post-thrombolysis END. NLR was related to post-thrombolysis ENI. The online version contains supplementary material available at 10.1186/s12974-021-02090-6.
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影响因子：
3.7
作者：
Curbelo J;Luquero Bueno S;Galván-Román JM;Ortega-Gómez M;Rajas O;Fernández-Jiménez G;Vega-Piris L;Rodríguez-Salvanes F;Arnalich B;Díaz A;Costa R;de la Fuente H;Lancho Á;Suárez C;Ancochea J;Aspa J
通讯作者：
Aspa J
影响因子：
9.3
作者：
Morang'a CM;Amenga-Etego L;Bah SY;Appiah V;Amuzu DSY;Amoako N;Abugri J;Oduro AR;Cunnington AJ;Awandare GA;Otto TD
通讯作者：
Otto TD
DOI：
10.1016/j.jstrokecerebrovasdis.2018.09.001
发表时间：
2019-01-01
影响因子：
2.5
作者：
Massiot, Nicolas;Lareyre, Fabien;Raffort, Juliette
通讯作者：
Raffort, Juliette
影响因子：
8.3
作者：
Nam, Ki-Woong;Kim, Tae Jung;Yoon, Byung-Woo
通讯作者：
Yoon, Byung-Woo
影响因子：
2.9
作者：
Mori, Mayumi;Naganuma, Masaki;Toyoda, Kazunori
通讯作者：
Toyoda, Kazunori